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. 2019 Jun 3;10:1201. doi: 10.3389/fmicb.2019.01201

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Copyright © 2019 Liang and Radosevich.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quorum sensing-mediated lysis-lysogeny decisions of phage VP882. The genes of phage VP882 are characterized in the repressed (Left Side) and induced (Right Side) pathways. gp56 encodes the VqmA_phage protein that can bind the host quorum-sensing autoinducer (DPO). The Q anti-terminator can activate lysis genes gp69-71 inducing lysis (Right), whereas cl represses q thereby promoting lysogeny (Left). At high cell density, high levels of host-produced DPO promotes Q-tip anti-repressor production. Q-tip then sequesters the cl repressor that allows Q to launch the lysis pathway. However, cl repressor can function at low cell density leading to lysogeny.