Table 2.
Quantitative imaging data as related to clinical outcome‡.
| eGOS ≤ 5 | eGOS > 5 | n of eGOS ≤ 5, n of eGOS > 5 | OR (95% CI) | p-value | AUC (95% CI) | PC | NPC | n of PC, n of NC | OR (95% CI) | p-value | AUC (95% CI) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age, years | 57·00 (48·00–65·00) | 52·00⁎ (44·00–59·00) | 69, 43 | 1·06 (1·02–1·10) | 0·0261 | 0·62 (0·51–0·73) | 57·00 (48·00–65·00) | 52·00⁎ (44·00–60·00) | 78, 46 | 1·04 (1·00–1·07) | 0·0351 | 0·62 (0·51–0·73) |
| WFNS | 4 (2–5) | 2⁎ (1–4·5) | 69, 43 | 1·60 (1·22–2·11) | 0·0007 | 0·66 (0·55–0·77) | 4 (2–5) | 2 (1–4·5)⁎ | 78, 46 | 1·56 91·21–2·01) | 0·0005 | 0·65 (0·55–0·75) |
| RMS | 7 (5–8) | 5⁎ [[3], [4], [5], [6], [7]] | 69, 43 | 1·73 (1·33–2·24) | 0·0002 | 0·75 (0·65–0·85) | 7 (5–8) | 5⁎ [[3], [4], [5], [6], [7]] | 78, 46 | 1·52 (1·22–1·90) | 0·0002 | 0·71 (0·62–0·81) |
| ABT volume, ml | ||||||||||||
| ABT1 | 85·24 (58·95–131·88) | 55·82 (34·79–98·11) | 69, 43 | 1·01 (1·00–1·02) | 0·0401 | 0·67 (0·58–0·79) | 84·31 (54·69–131·57) | 56·25 (35·19–102·02) | 78, 46 | 1·01 (1·00–1·02) | 0·0410 | 0·66 (0·57–0·79) |
| ABT2 | 111·46† (80·47–219·23) | 68·05⁎ (33·05–105·38) | 42, 24 | 1·02 (1·01–1·04) | 0·0040 | 0·74 (0·62–0·88) | 109·88† (80·47–219·23) | 67·46⁎ (33·05–115·15) | 47, 25 | 1·02 (1·01–1·03) | 0·0045 | 0·74 (0·62–0·87 |
| ABT3 | 134·98† (91·94–199·37) | 59·75⁎ (28·68–93·24) | 62, 37 | 1·02 (1·01–1·04 | 0·0002 | 0·83 (0·74–0·92) | 134·55† (91·42–205·27) | 61·39⁎ (30·71–102·64) | 71, 40 | 1·02 (1·01–1·03) | 0·0003 | 0·80 (0·71–0·89 |
| ABT4 | 138·71† (102·79–204·39) | 29·55⁎† (15·78–73·55) | 36, 33 | 1·03 (1·02–1·05) | 0·0002 | 0·88 (0·81–0·97) | 138·66† (99·23–204·39) | 29·55⁎† (16·92–71·70) | 37, 33 | 1·03 (1·02–1·05) | 0·0002 | 0·88 (0·80–0·96 |
| NBT volume, ml | ||||||||||||
| NBT1 | 1496·3‡ (1359·1–1568·5) | 1461·8‡ (1370·5–1530·8) | 69, 43 | ·· | 0·7218 | ·· | 1503·0‡ (1401·2–1575·0) | 1455·6‡ (1364·4–1522·0) | 78, 46 | ·· | 0· 4101 | ·· |
| NBT2 | 1425·2‡ (1349·7–1534·9) | 1452·0‡ (1384·1–1515·1) | 42, 24 | ·· | 0·4159 | ·· | 1425·7‡ (1350·1–1534·9) | 1440·8‡ (1377·1–1515·1) | 47, 25 | ·· | 0·5738 | ·· |
| NBT3 | 1383·3†‡ (1276·6–1480·7) | 1451·4‡ (1373·2–1531·6) | 62, 37 | ·· | 0·0869 | ·· | 1390·0 †‡ (1287·5–1495·1) | 1442·5‡ (1366·6–1521·4) | 71, 40 | ·· | 0·0908 | ·· |
| NBT4 | 1347·4†‡ (1198·6–1411·8) | 1475·5⁎‡ (1410·8–1542·3) | 36, 33 | 0·99 (0·98–1·00) | 0·0025 | 0·81 (0·70–0·91) | 1351·8† ‡ (1198·6–1437·0) | 1469·3⁎‡ (1389·9–1537·0) | 37, 33 | 0·99 (0·99–1·00) | 0·0055 | 0·77 (0·66–0·89) |
| LV volume, ml | ||||||||||||
| LV1 | 36·59‡ (22·59–57·57) | 35·13‡ (23·18–48·08) | 69, 43 | ·· | 0·7216 | ·· | 33·81‡ (20·36–51·44) | 35·18‡ (23·81–49·51) | 78, 46 | ·· | 0·9792 | ·· |
| LV2 | 34·30‡ (18·44–50·59) | 27·86 (21·31–37·19) | 42, 24 | ·· | 0·8668 | ·· | 30·47‡ (17·92–49·00) | 27·52‡ (21·31–37·19) | 47, 25 | ·· | 0·9723 | ·· |
| LV3 | 40·04‡ (22·00–60·38) | 35·87‡ (22·00–54·46) | 62, 37 | ·· | 0·2754 | ·· | 38·29‡ (23·10–60·27) | 36·32‡ (27·60–54·46) | 71, 40 | ·· | 0·8910 | ·· |
| LV4 | 68·29†‡ (47·98–108·98) | 45·62⁎†‡ (32·07–69·85) | 36, 33 | 1·02 (1·00–1·03) | 0·0153 | 0·67 (0·54–0·80 | 71·51†‡ (50·90–109·39) | 44·69⁎‡ (30·77–56·16) | 37, 33 | 1·03 (1·01–1·05) | 0·0012 | 0·74 (0·62–0·86) |
| SAS volume, ml | ||||||||||||
| SAS1 | 267·08‡ (154·80–379·21) | 228·55‡ (150·32–344·57) | 69, 43 | ·· | 0·2901 | ·· | 257·66‡ (148·10–354·18) | 246·45‡ (160·75–377·70) | 78, 46 | ·· | 0·8161 | ·· |
| SAS2 | 159·26† (107·35–296·91) | 195·45 (147·68–298·13) | 42, 24 | ·· | 0·3408 | ·· | 157·28† (104·13–296·91) | 196·00 (147·69–319·27) | 47, 25 | ·· | 0·2162 | ·· |
| SAS3 | 231·66‡ (154·20–337·51) | 233·05‡ (145·36–349·60) | 62, 37 | ·· | 0·6926 | ·· | 221·41‡ (148·19–333·90) | 257·89‡ (187·68–401·95) | 71, 40 | ·· | 0·5036 | ·· |
| SAS4 | 447·19†‡ (272·10–564·83) | 361·93⁎†‡ (281·57–481·77) | 36, 33 | ·· | 0·1223 | ·· | 450·92†‡ (272·10–564·83) | 363·43⁎†‡ (281·57–497·71) | 37, 33 | ·· | 0·1584 | ·· |
| ABTBBBD volume, ml | ||||||||||||
| ABTBBBD1 | 19·23 (9·53–24·57) | 11·72⁎ (9·08–22·17) | 49, 30 | 1·06 (1·01–1·11) | 0·0109 | 0·68 (0·55–0·80) | 23·02 (12·01–31·08) | 12·13⁎ (9·23–22·83) | 59, 34 | 1·05 (1·01–1·09) | 0·0177 | 0·66 (0·54–0·78) |
| ABTBBBD2 | 27·60† (14·83–48·23) | 19·20⁎ (8·68–25·24) | 32, 18 | 1·05 (1·01–1·10) | 0·0184 | 0·69 (0·52–0·86) | 39·11† (19·06–60·50) | 18·80⁎ (7·82–24·73) | 35, 20 | 1·06 (1·01–1·11) | 0·0088 | 0·72 (0·56–0·88) |
| ABTBBBD3 | 35·88† (23·77–56·47) | 14·55⁎ (8·84–36·32) | 50, 28 | 1·05 (1·02–1·08) | 0·0004 | 0·79 (0·68–0·90) | 44·14† (28·15–71·10) | 15·54⁎ (8·83–37·41) | 58, 30 | 1·05 (1·02–1·08) | 0·0002 | 0·78 (0·67–0·89) |
| ABTBBBD4 | 19·91 (13·12–43·18) | 5·90⁎† (2·89–13·87 | 23, 21 | 1·07 (1·02–1·13) | 0·0071 | 0·85 (0·73–0·97) | 24·38 (18·23–50·99) | 5·84⁎† (2·89–11·33) | 24, 22 | 1·08 (1·02–1·14) | 0·0077 | 0·85 (0·73–0·97) |
| NBTBBBD volume, ml | ||||||||||||
| NBTBBBD1 | 127·05‡ (109·78–160·60) | 106·70⁎‡ (62·94–128·60) | 49, 30 | 1·02 (1·01–1·04) | 0·0017 | 0·73 (0·61–0·82) | 129·47‡ (111·38–161·72) | 102·08⁎‡ (65·53–127·64) | 59, 34 | 1·03 (1·01–1·04) | 0·0003 | 0·73 (0·62–0·84) |
| NBTBBBD2 | 135·41a (90·94–180·24) | 90·94⁎‡ (64·84–115·12) | 32, 18 | 1·03 (1·01–1·05) | 0·0086 | 0·80 (0·64–0·94) | 140·32‡ (104·34–191·58) | 90·23⁎‡ (62·70–102·74) | 35, 20 | 1·04 (1·02–1·07) | 0·0019 | 0·84 (0·71–0·97) |
| NBTBBBD3 | 127·72‡ (102·66–167·98) | 94·63⁎‡ (72·22–110·45) | 50, 28 | 1·02 (1·01–1·04) | 0·0016 | 0·77 (0·65–0·88) | 127·72‡ (102·66–167·98) | 94·63⁎‡ (70·52–109·71) | 58, 30 | 1·03 (1·01–1·05) | 0·0002 | 0·77 (0·66–0·88) |
| NBTBBBD4 | 105·61†‡ (79·18–146·66) | 69·87⁎†‡ (54·99–97·62) | 23, 21 | 1·03 (1·01–1·05) | 0·0114 | 0·75 (0·61–0·90) | 110·68†‡ (79·21–147·64) | 67·52⁎†‡ (54·99–92·29) | 24, 22 | 1·04 (1·01–1·07) | 0·0031 | 0·79 (0·65–0·93) |
| ABTBBBD10volume, ml | ||||||||||||
| ABTBBBD110 | 42·19 (28·51–60·71) | 29·19⁎ (17·29–46·95) | 49, 30 | 1·04 (1·01–1·06) | 0·0092 | 0·66 (0·53–0·78) | 45·78 (28·68–65·18) | 29·63⁎ (18·58–45·26) | 59, 34 | 1·04 (1·01–1·06) | 0·0077 | 0·67 (0·54–0·79) |
| ABTBBBD210 | 51·74 (38·48–72·96) | 28·42⁎ (15·92–47·61) | 32, 18 | 1·05 (1·01–1·08) | 0·0076 | 0·77 (0·62–0·93) | 55·58 (40·57–74·87) | 28·42⁎ (13·77–43·44) | 35, 20 | 1·09 (1·04–1·16) | 0·0001 | 0·81 (0·67–0·95) |
| ABTBBBD310 | 52·14 (34·98–74·48) | 28·11⁎ (17·88–38·96) | 50, 28 | 1·04 (1·01–1·06) | 0·0022 | 0·76 (0·65–0·88) | 52·14 (34·98–74·48) | 28·11⁎ (17·82–39·98) | 58, 30 | 1·05 (1·02–1·07) | 0·0004 | 0·76 (0·64–0·87) |
| ABTBBBD410 | 36·67† (24·35–54·67) | 9·98⁎† (6·65–23·52) | 23, 21 | 1·08 (1·03–1·14) | 0·0012 | 0·85 (0·73–0·97) | 36·66† (24·74–54·31) | 9·47⁎† (6·65–20·89) | 24, 22 | 1·09 (1·04–1·16) | 0·0009 | 0·87 (0·76–0·98) |
| ABTBBBD20volume, ml | ||||||||||||
| ABTBBBD120 | 38·89 (29·32–47·82) | 27·50 (20·35–48·14) | 49, 30 | 1·02 (0·99–1·05) | 0·0824 | 0·61 (0·48–0·74) | 39·16 (30·12–48·89) | 30·41⁎ (21·07–42·53) | 59, 34 | 1·03 (1·00–1·06) | 0·0264 | 0·64 (0·52–0·76) |
| ABTBBBD220 | 35·51 (30·21–50·70) | 28·61⁎ (16·60–34·74) | 32, 18 | 1·06 (1·01–1·12) | 0·0225 | 0·76 (0·53–0·87) | 35·59 (27·83–50·98) | 25·02⁎ (15·84–34·51) | 35, 20 | 1·09 (1·03–1·16) | 0·0040 | 0·77 (0·60–0·91) |
| ABTBBBD320 | 33·71 (26·32–44·09) | 25·64⁎ (17·03–32·99) | 50, 28 | 1·06 (1·02–1·11) | 0·0049 | 0·74 (0·58–0·83) | 33·71 (25·42–44·35) | 25·64⁎ (16·70–30·37) | 58, 30 | 1·07 (1·03–1·12) | 0·0013 | 0·74 (0·59–0·83) |
| ABTBBBD420 | 34·60 (29·37–50·75) | 18·39⁎ (7·76–30·01) | 23, 21 | 1·08 (1·02–1·14) | 0·0039 | 0·79 (0·65–0·92) | 34·69 (29·73–50·28) | 17·94⁎† (7·76–28·12) | 24, 22 | 1·10 (1·03–1·17) | 0·0017 | 0·82 (0·67–0·95) |
OR = odds ratio. PC = progressive course of aSAH. NPC = non-progressive course of aSAH.
Significant difference ≤ 0·05 between outcome groups (eGOS ≤ 4, vs eGOS > 4, or PC vs NC) with Wilcoxon sum-rank test⁎. Significant difference ≤ 0·05 between different time points with Friedman test†. Significant difference ≤ 0·05 between control and a measurement at a single time point with Wilcoxon sum-rank test‡. The area under the ROC curve (AUC) results were considered “excellent” for AUC values between 0·9–1, “good” for AUC values between 0·8–0·9, “fair” for AUC values between 0·7–0·8, “poor” for AUC values between 0·6–0·7 and failed for AUC values between 0·5–0·6.
‡
Only significant OR values were presented in the table.