. 2019 Jun 3;43:460–472. doi: 10.1016/j.ebiom.2019.04.054

Table 3.

Investigation of a voxel fate:

Probability of turnover of a normal brain tissue voxel at t1 to turn into ABT at t4:
	ABT¹⁰	ABT²⁰	ABT^>20	n
NBTBBBD₁	0·284^{⁎,⁎⁎⁎} (0·122–0·594)	0·196^⁎ (0·106–0·412)	0·212^⁎ (0·099–0·464)	70
$NBT {\tilde{BBBD}}_{1}$	0·089 (0·068–0·141)	0·063 (0·045–0·101)	0·069 (0·052–0·117)	70

Probability of persistence of an abnormal brain tissue voxel with BBBD to remain ABT at t4:
	Total	n
ABTBBBD₁	0·697 (0·584–0·841)^⁎⁎	70
ABTBBBD₂	0·721 (0·596–0·838)^⁎⁎	61
ABTBBBD₃	0·740 (0·630–0·937)^⁎⁎	64

Probability of persistence of an abnormal brain tissue voxel without BBBD to remain ABT at t4:
	Total	n
$ABT {\tilde{BBBD}}_{1}$	0·244 (0·102–0·348)	70
$ABT {\tilde{BBBD}}_{2}$	0·252 (0·121–0·377)	61
$ABT {\tilde{BBBD}}_{3}$	0·242 (0·114–0·353)	64

^⁎Significant difference between probabilities of a normal brain tissue (NBT) voxel with blood brain barrier damage (BBBD) (NBTBBBD₁) and without BBBD ( $NBT {\tilde{BBBD}}_{1}$ ) to become an abnormal brain tissue (ABT₄) voxel at t4 (p < 0·05, Wilcoxon sum-rank test).

^⁎⁎Significant difference between probabilities of ABT voxel with BBBD (ABTBBBD_j) and without BBBD ( $ABT {\tilde{BBBD}}_{j}$ ) to remain an ABT₄ voxel at t4 (where j = 1, …,3 denotes time interval t1-t3) (p < 0·05, Wilcoxon sum-rank test).

^⁎⁎⁎Significant difference between different regions: ABT¹⁰, ABT²⁰ and ABT^>20 (p < 0·05, Kruskal-Wallis test).