Table 1. Characteristics of panel of dMMR CRC samples.
MLH1: mutL homolog 1; PMS2: PMS1 homolog 2, mismatch repair system component; MSH2: mutS homolog 2; MSH6: mutS homolog 6. F: female; M: male.
| Sample | Sex | Age | Tumor location | Stage | Primary tumor / metastasis | Biopsy / resection | Absent MMR stains |
|---|---|---|---|---|---|---|---|
| CRC-1 | F | 68 | Colon | I | Primary tumor | Resection | MLH1/PMS2 |
| CRC-2 | M | 65 | Colon | III | Primary tumor | Resection | MSH6 |
| CRC-3 | F | 65 | Colon | II | Primary tumor | Resection | MLH1/PMS2 |
| CRC-4 | F | 75 | Colon | III | Primary tumor | Resection | MLH1/PMS2 |
| CRC-5 | F | 73 | Rectum | I | Primary tumor | Resection | MSH6 |
| CRC-6P | F | 67 | Colon | IV | Primary tumor | Resection | MLH1/PMS2 |
| CRC-6M | F | 67 | Peritoneum | IV | Metastasis | Resection | MLH1/PMS2 |
| CRC-7 | F | 62 | Colon | III | Primary tumor | Resection | MLH1/PMS2 |
| CRC-8P | M | 50 | Colon | IV | Primary tumor | Resection | MLH1/PMS2 |
| CRC-8M | M | 50 | Liver | IV | Metastasis | Resection | MLH1/PMS2 |
| CRC-9 | F | 51 | Lymph node (neck) | IV | Metastasis | Biopsy | MLH1/PMS2 |
| CRC-10 | F | 66 | Liver | IV | Metastasis | Biopsy | MLH1/PMS2 (partial loss of MSH6) |
| CRC-11 | F | 66 | Peritoneum | IV | Metastasis | Biopsy | MLH1/PMS2 |
| CRC-12 | F | 74 | Colon | I | Primary tumor | Resection | MLH1/PMS2 |
| CRC-13 | F | 70 | Colon | II | Primary tumor | Biopsy | MLH1/PMS2 |