Table 1.
Drosophila and Mammalian Hippo pathway components.
| Drosophila | Mammals | Conserved domains |
|---|---|---|
| Hippo | MST1/2 | Ste20 Ser/Thr kinase and SARAH domains |
| Warts | LATS1/2 | NDR Ser/Thr kinase domain |
| Salvador | WW45/SAV1/WWP4 | WW and SARAH |
| Mats | MOBKL1 A and B | Cys2-His2 zinc-binding site/Mob1/phocein domain |
| Yorkie | YAP/TAZ | WW/PDZ and TEAD binding domain |
| Scalloped | TEAD 1-4 transcription factors | TEA/ATTS and Yki/YAP-binding domains |
| Merlin | NF2 | FERM domain |
| Kibra | WWC1/WWC2 | WW and C2 domains |
| Expanded | FRMD6 or Willin (human expanded) | FERM domain |
| Tao-1 | TAO 1-3 | Protein kinase domain |
| Crumbs | CRB 1-3 | EGF like and Laminin G domains, PDZ and FERM binding motifs |
| Lethal giant larvae | Lethal Giant Larvae 1-2 | LGL2 domain |
| aPKC | aPKCλ, aPKCς | PKC kinase, PB1 and C1 domains |
| Mop | His domain phosphotyrosine phosphatase (HDPTP) | PTP motifs |
| dJub | Ajuba, LIM proteins/LIMD1/WTIP | LIM domains |
| dZyx or Zyx102 | Zyxin | C-terminal LIM domains |
| Fat | Fat 1-4/Fat-j | EGF-like, Laminin G and Cadherin repeat domains |
| Daschsous | Dchs ½ | Cadherin repeat domain |
| Disk overgrown | CK1δ, CK1𝜀 | Ser/Thr kinase domain |
| Low fat | Lix1, Lix1L | Unknown |
| Scribble | Scribble | PDZ domains |
| Disks large | Disks Large | L27/PDZ/SH3 domains |
| dMnt | Mad | Basic helix-loop-helix-zipper, Sin-interacting domain |
| Homothorax | MEIS1 | HM (Homothorax-Meis) domain and homeodomain |
| Tea-shirt | TSH3 | Zinc finger domain |
| Pat J | PAT J | Common L27 domain |
| Par 1/6 | PAR1/6 | PDZ domains |
| dRASSF | RASSF1-6 | Ras association and SARAH domains |
| Stardust | PALS-1/Mpp5 | L27/PDZ/SH3 domain and guanylate kinase like domain |
| Tgi | VGLL4 | TDU domains |
| dSTRIPAK PP2A | STRIPAK PP2A | PP2A Ser/Thr phosphatase complex |