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. 2019 May 29;10:1166. doi: 10.3389/fimmu.2019.01166

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Copyright © 2019 Blois, Dveksler, Vasta, Freitag, Blanchard and Barrientos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simplified schematic representation of N-and O-glycan biosynthesis focusing on galectin-1 binding affinity. N-glycans are attached to asparagine (Asn) residues, whereas O-glycans are attached to either serine (Ser) or threonine (Thr) residues. Gal-1 recognizes galactose on complex N-glycans and sialylation on the terminal galactose in the α2,6-linkage, but not in the α2,3-linkage, prevents the binding of gal-l. Regarding O-glycans, gal-1 binds to the N-acetyllactosamine (LacNAc) motif in core 2 O-glycans. ST6GAL-1, β-galactoside α2,6-sialyltransferase 1; MGATS, α1,6-mannosylglycoprotein 6β-N-acetylglucosaminyltransferase; C2GnT, core 2 β1,6 N-acetylglucosaminyltransferase.