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. 2019 May 29;10:1199. doi: 10.3389/fimmu.2019.01199

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Copyright © 2019 Yang, He, Zhang, Mi and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Suppression of inflammatory cell infiltration and cytokine release from MSU-induced air pouch model in T-bet-deficient mice. (A) total cell number was counted by a hematocytometer. (B) neutrophils and macrophages were gated by flow cytometry. Infiltrated macrophages were represented by F4/80⁺, and neutrophils by Ly6G⁺. (C,D) Infiltrated neutrophils (C) and macrophages (D) were analyzed using flow cytometry. (E) IL-1β protein levels in air pouch lavage fluid were measured at 3 and 6 h using enzyme-linked immunosorbent assays. Results are representative of 3 independent experiments. n = 3–5 for each group and unpaired t-test was used for each group at indicated time points. *P < 0.05. IL, interleukin; KO, knockout; MSU, monosodium urate; WT, wild type.