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. 2019 May 31;10:620. doi: 10.3389/fphar.2019.00620

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Copyright © 2019 Zhang, Han, Xue, Deng, Wu, Peng, Zhang, Xuan, Pan and Fu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AG490 or MLB+AG490 pretreatment affected oxidative stress in liver and inhibited inflammatory factors’ expression. (A, B) The expression of SOD and MDA in liver tissue of sham, I/R, MLB, and AG490 groups. (C–E) Serum IL-6, IL-1β, and TNF-α were detected by ELISA in sham, I/R, MLB, and AG490 groups. (F–G) The expression of SOD and MDA in liver tissue of sham, I/R, MLB, and MLB+AG490 groups. (H–J) Serum IL-6, IL-1β, and TNF-α were detected by ELISA in sham, I/R, MLB, and MLB+AG490 groups. The data are expressed as mean ± SD; n = 5 for each group; ns: no statistical significance; ^###P < 0.001 versus sham group; *P < 0.05, **P < 0.01, and ***P < 0.001 versus I/R group; ^&&&P < 0.001 versus MLB group.