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. 2019 May 23;10(6):1479–1488. doi: 10.1111/1759-7714.13097

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© 2019 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Interruption of CBLL1 decreased the cell invasive abilities of A549 and H1299 cells. (a) Cell invasion was examined using transwell chambers with Matrigel. The representative microscopic fields of invasive cells transfected with CBLL1 siRNA and negative control siRNA, respectively. Knockdown of CBLL1 greatly suppressed invasion in A549 and H1299 cells (P < 0.001). The histogram showed that the number of cells invaded (A549 and H1299) transfected with CBLL1 siRNA was significantly fewer (P < 0.001) than cells transfected with negative control siRNA (right panel)，***P < 0.001. (b) Western blot analysis of cell cycle‐related and invasion‐related proteins in A549 and H1299 cells with CBLL1 depletion. (c) Realtime RT‐PCR results showed that E‐cadherin mRNA expression level was not changed after CBLL1 depletion in A549 and H1299 cells，***P < 0.001. siNC, siCBLL1.

Inline graphic — Interruption of CBLL1 decreased the cell invasive abilities of A549 and H1299 cells. (a) Cell invasion was examined using transwell chambers with Matrigel. The representative microscopic fields of invasive cells transfected with CBLL1 siRNA and negative control siRNA, respectively. Knockdown of CBLL1 greatly suppressed invasion in A549 and H1299 cells (P < 0.001). The histogram showed that the number of cells invaded (A549 and H1299) transfected with CBLL1 siRNA was significantly fewer (P < 0.001) than cells transfected with negative control siRNA (right panel)，***P < 0.001. (b) Western blot analysis of cell cycle‐related and invasion‐related proteins in A549 and H1299 cells with CBLL1 depletion. (c) Realtime RT‐PCR results showed that E‐cadherin mRNA expression level was not changed after CBLL1 depletion in A549 and H1299 cells，***P < 0.001. siNC, siCBLL1.