Table 1.
Demographics and clinicopathological characteristics of patients with urinary tract urothelial carcinoma included in present study
| Characteristic | Total | PNI ＜46.91 (n = 298, 47.6%) | PNI ≥ 46.91 (n = 419, 52.4%) | P |
|---|---|---|---|---|
| Gender (male vs female) | 408/309 | 172/126 | 236/183 | 0.710 |
| Age (>67 vs <67 years) | 354/363 | 160/138 | 194/225 | 0.051 |
| Body mass index (≥25 vs <25 kg/m2) | 188/529 | 70/228 | 118/301 | 0.161 |
| Smoking history (yes vs no) | 204/513 | 89/209 | 115/304 | 0.479 |
| Tumor side (right vs left) | 350/367 | 154/144 | 196/223 | 0.196 |
| Surgical approach, n (%) | 0.646 | |||
| Open RNU | 484 (67.5) | 204 (68.5) | 280 (66.8) | |
| Laparoscopic RNU | 233 (32.5) | 94 (31.5) | 139 (33.2) | |
| Hydronephrosis (Yes vs No) | 447/270 | 177/121 | 270/149 | 0.170 |
| Tumor location, n (%) | 0.013 | |||
| Pelvicalyceal | 385 (53.7) | 169 (56.7) | 216 (51.6) | |
| Ureteric | 205 (28.6) | 69 (23.2) | 136 (32.5) | |
| Both | 127 (17.7) | 60 (20.1) | 67 (16.0) | |
| Tumor grade (High vs Low) | 528/189 | 239/59 | 289/130 | 0.001 |
| Tumor stage, n (%) | <0.001 | |||
| Tis, Ta, T1 | 221 (30.8) | 74 (24.8) | 147 (35.1) | |
| T2 | 145 (20.2) | 56 (18.8) | 89 (21.2) | |
| T3 | 248 (34.6) | 107 (35.9) | 141 (33.7) | |
| T4 | 103 (14.4) | 61 (20.5) | 42 (10.0) | |
| Lymph node status, n (%) | 0.434 | |||
| pN0 | 90 (12.6) | 41 (13.8) | 49 (11.7) | |
| pNx | 556 (77.5) | 224 (75.2) | 332 (79.2) | |
| pN+ | 71 (9.9) | 33 (11.1) | 38 (9.1) | |
| LVI (positive vs negative) | 107/610 | 54/244 | 53/366 | 0.043 |
| Tumor size (＞3 vs ≤3 cm) | 488/229 | 207/91 | 281/138 | 0.497 |
| Surgical margin status (positive vs negative) | 58/659 | 26/272 | 32/387 | 0.599 |
| Multifocality (present vs absent) | 119/598 | 45/253 | 74/345 | 0.364 |
| Sessile vs papillary | 492/225 | 223/75 | 269/150 | 0.002 |
| CVH (with vs without) | 165/552 | 80/218 | 85/334 | 0.040 |
| Bladder cancer status, n (%) | 0.930 | |||
| No | 616 (85.9) | 255 (85.6) | 361 (86.2) | |
| Previous | 22 (3.1) | 10 (3.4) | 12 (2.9) | |
| Concomitant | 79 (11.0) | 33 (11.1) | 46 (11.0) | |
| Adjuvant therapy (yes vs no) | 291/426 | 117/181 | 174/245 | 0.543 |
| Serum albumin (g/L) | 39.74 ± 5.03 | 35.53 ± 4.36 | 42.74 ± 2.85 | <0.001 |
| Lymphocyte count (109) | 1.73 ± 6.51 | 1.12 ± 0.43 | 2.17 ± 8.49 | 0.184 |
Abbreviations: RNU, radical nephroureterectomy; LVI, lymphovascular invasion; CVH, concomitant variant histology.