Table 1.

Cox multivariate analyses for the duration of DFS

Final model	HR (95% CI)	P‐value
Classic
Mitoses	3.5 (1.4‐8.3)	0.005*
Extrascleral extension	8 (2.5‐25.2)	<0.001*
M3	3.1 (1.1‐9.1)	0.04*
Isochromosome 8q	4.2 (1.7‐10.3)	0.002*
Clinical
Stage	2.5 (1.1‐5.8)	0.03*
Extrascleral extension	3.2 (1.2‐8.3)	0.02*
Histology
Epithelioid component	2.1 (1.0‐4.1)	0.04*
Mitotic activity	2.9 (1.3‐6.5)	0.008*
Necrosis	2.1 (1.0‐4.6)	0.06
CNA
M3	11.0 (3.4‐35.7)	<0.001*
8q+	3.9 (1.6‐9.2)	0.002*
LZTS1 deletion	5.3 (2.2‐12.8)	<0.001*
NBL1 deletion	5.3 (2.2‐13.0)	<0.001*
Immune‐CNA
M3	9.2 (2.7‐31.1)	<0.001*
8q+	3.6 (1.5‐8.7)	0.005*
LZTS1 deletion	4.6 (1.8‐11.6)	0.001*
NBL1 deletion	5.8 (2.3‐14.8)	<0.001*
Immune infiltratea	1.6 (0.7‐3.7)	0.2

^aImmune forced into the model.

^* P ≤ 0.05 considered significant.