Figure 2.

IL-22 stimulation leads to lymphocyte proliferation, which in turn accelerates the synthesis of molecules, elimination of germs, and desquamation. Thus, the epidermis can participate in innate and adaptive immunity in response to infection or stimulation with cytokines. This is due to an increase in the levels of molecules, such as AMP; in the production of chemokines, such as IFN-α, TSL, and TSLP; and in the number of Th17 and IL-17-producing CD4+ and CD8+ T cells and T- helper cells (Th). This mechanism responds to the pathogenesis of psoriasis.