Table 2.
Frequencies of elevated marker levels in seminoma and nonseminoma at the time of diagnosis.
| bHCG elevated | AFP elevated | LDH elevated | bHCG and AFP elevated | bHCG and LDH elevated | AFP and LDH elevated | bHCG, AFP and LDH elevated | bHCG or AFP elevated | bHCG, AFP or LDH elevated | ||
|---|---|---|---|---|---|---|---|---|---|---|
| N | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | |
| 95% CI [%] | 95% CI [%] | 95% CI [%] | 95% CI [%] | 95% CI [%] | 95% CI [%] | 95% CI [%] | 95% CI [%] | 95% CI [%] | ||
| Seminoma | 254 | 71 (28.0%) | 7 (2.8%) | 74 (29.1%) | 1 (0.4%) | 34 (13.4%) | 4 (1.6%) | 1 (0.4%) | 77 (30.3%) | 114 (44.9%) |
| 22.6 - 34.0 | 1.2 - 5.8 | 23.7 - 35.2 | 0.0 - 2.5 | 9.6 - 18.3 | 0.5 - 4.3 | 0.0 - 2.5 | 24.8 - 36.4 | 38.7 - 51.2 | ||
| Nonseminoma | 168 | 89 (53.0%) | 101 (60.1%) | 65 (38.7%) | 66 (39.3%) | 39 (23.2%) | 42 (25.0%) | 29 (17.3%) | 124 (73.8%) | 137 (81.5%) |
| 45.2 - 60.7 | 52.3 - 67.5 | 31.4 - 46.5 | 31.9 - 47.1 | 17.2 - 30.5 | 18.8 - 32.4 | 12.0 - 24.0 | 66.4 - 80.1 | 74.7 - 86.9 | ||
| p-valuea | <.0001 | <.0001 | 0.0367 | <.0001 | 0.0082 | <.0001 | <.0001 | <.0001 | <.0001 | |
| CS1 vs. >CS1 (Seminoma) | ||||||||||
| CS1 | 201 | 49 (24.4%) | 4 (2.0%) | 46 (22.9%) | 0 (0.0%) | 17 (8.5%) | 3 (1.5%) | 0 (0.0%) | 53 (26.4%) | 79 (39.3%) |
| 18.7 - 31.0 | 0.6 - 5.3 | 17.4 - 29.4 | 0.0 - 2.3 | 5.2 - 13.4 | 0.4 - 4.7 | 0.0 - 2.3 | 20.5 - 33.1 | 32.6 - 46.4 | ||
| >CS1 | 53 | 22 (41.5%) | 3 (5.7%) | 28 (52.8%) | 1 (1.9%) | 17 (32.1%) | 1 (1.9%) | 1 (1.9%) | 24 (45.3%) | 35 (66.0%) |
| 28.4 - 55.8 | 1.5 - 16.6 | 38.8 - 66.5 | 0.1 - 11.4 | 20.3 - 46.4 | 0.1 - 11.4 | 0.1 - 11.4 | 31.8 - 59.4 | 51.6 - 78.1 | ||
| p-valuea | 0.0134 | 0.1465 | <.0001 | 0.0510 | <.0001 | 0.8375 | 0.0510 | 0.0077 | 0.0005 | |
| CS1 vs. >CS1 (Nonseminoma) | ||||||||||
| CS1 | 80 | 37 (46.3%) | 50 (62.5%) | 18 (22.5%) | 31 (38.8%) | 8 (10.0%) | 12 (15.0%) | 8 (10.0%) | 56 (70.0%) | 62 (77.5%) |
| 35.2 - 57.7 | 50.9 - 72.9 | 14.2 - 33.5 | 28.3 - 50.3 | 4.7 - 19.3 | 8.3 - 25.1 | 4.7 - 19.3 | 58.6 - 79.5 | 66.5 - 85.8 | ||
| >CS1 | 88 | 52 (59.1%) | 51 (58.0%) | 47 (53.4%) | 35 (39.8%) | 31 (35.2%) | 30 (34.1%) | 21 (23.9%) | 68 (77.3%) | 75 (85.2%) |
| 48.1 - 69.3 | 47.0 - 68.2 | 42.5 - 64.0 | 29.7 - 50.8 | 25.5 - 46.2 | 24.5 - 45.1 | 15.7 - 34.4 | 66.9 - 85.2 | 75.7 - 91.6 | ||
| p-valuea | 0.0958 | 0.5479 | <.0001 | 0.8922 | 0.0001 | 0.0049 | 0.0193 | 0.2843 | 0.1972 | |
| Nonseminoma with teratoma | ||||||||||
| No teratoma | 88 | 40 (45.5%) | 43 (48.9%) | 36 (40.9%) | 27 (30.7%) | 17 (19.3%) | 20 (22.7%) | 11 (12.5%) | 56 (63.6%) | 66 (75.0%) |
| 34.9 - 56.4 | 38.1 - 59.7 | 30.7 - 51.9 | 21.5 - 41.5 | 12.0 - 29.4 | 14.8 - 33.1 | 6.7 - 21.7 | 52.6 - 73.4 | 64.4 - 83.4 | ||
| With teratoma | 80 | 49 (61.3%) | 58 (72.5%) | 29 (36.3%) | 39 (48.8%) | 22 (27.5%) | 22 (27.5%) | 18 (22.5%) | 68 (85.0%) | 71 (88.8%) |
| 49.7 - 71.7 | 61.2 - 81.6 | 26.0 - 47.8 | 37.5 - 60.1 | 18.4 - 38.8 | 18.4 - 38.8 | 14.2 - 33.5 | 74.9 - 91.7 | 79.2 - 94.4 | ||
| p-valuea | 0.0405 | 0.0018 | 0.5783 | 0.0166 | 0.1933 | 0.4464 | 0.0798 | 0.0017 | 0.0218 | |
a Chi square test for comparisons of subgroups.