Table 2.
The association of orthostatic hypotension at 3 different times, the average, or a minimum of 3 standing measurements with dizziness upon standing, fall in the previous year, or fracture in the previous year
| Dizziness, N = 422/8,450 visits | Falls, N = 986/5,070 visits | Fracture, N = 151/5,071 visits | ||||
|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
| SBP per −10 mm Hg | ||||||
| M1 | 1.16 (1.07, 1.26) | 0.0002 | 1.05 (0.99, 1.11) | 0.12 | 1.03 (0.89, 1.20) | 0.66 |
| M2 | 1.16 (1.07, 1.26) | 0.0004 | 1.03 (0.97, 1.10) | 0.28 | 1.13 (0.97, 1.31) | 0.12 |
| M3 | 1.12 (1.03, 1.22) | 0.01 | 1.03 (0.97, 1.09) | 0.39 | 1.01 (0.88, 1.16) | 0.85 |
| Ave | 1.18 (1.08, 1.29) | 0.0002 | 1.04 (0.98, 1.11) | 0.20 | 1.07 (0.91, 1.25) | 0.41 |
| Min | 1.21 (1.12, 1.31) | <0.0001 | 1.08 (1.01, 1.14) | 0.02 | 1.09 (0.94, 1.28) | 0.26 |
| Systolic orthostatic hypotension (drop in SBP ≥ 20 mm Hg) | ||||||
| M1 | 1.90 (1.33, 2.72) | 0.0004 | 1.36 (0.99, 1.87) | 0.06 | 1.66 (0.86, 3.20) | 0.13 |
| M2 | 2.49 (1.71, 3.61) | <0.0001 | 1.49 (1.06, 2.11) | 0.02 | 2.86 (1.61, 5.08) | 0.0003 |
| M3 | 2.10 (1.43, 3.09) | 0.0002 | 1.35 (0.94, 1.92) | 0.10 | 1.15 (0.51, 2.58) | 0.74 |
| Ave | 2.82 (1.91, 4.18) | <0.0001 | 1.64 (1.11, 2.42) | 0.01 | 2.08 (1.00, 4.31) | 0.0501 |
| Min | 2.09 (1.57, 2.79) | <0.0001 | 1.29 (1.00, 1.67) | 0.0504 | 1.80 (1.07, 3.03) | 0.03 |
| DBP per −10 mm Hg | ||||||
| M1 | 1.16 (1.01, 1.32) | 0.04 | 1.02 (0.93, 1.13) | 0.62 | 1.01 (0.80, 1.28) | 0.93 |
| M2 | 1.05 (0.92, 1.20) | 0.46 | 0.95 (0.87, 1.05) | 0.33 | 0.99 (0.79, 1.25) | 0.96 |
| M3 | 1.07 (0.93, 1.23) | 0.32 | 0.95 (0.86, 1.04) | 0.28 | 0.93 (0.74, 1.16) | 0.51 |
| Ave | 1.11 (0.96, 1.29) | 0.16 | 0.97 (0.87, 1.08) | 0.58 | 0.97 (0.75, 1.26) | 0.82 |
| Min | 1.14 (0.99, 1.30) | 0.06 | 0.99 (0.89, 1.09) | 0.78 | 0.98 (0.77, 1.26) | 0.90 |
| Diastolic orthostatic hypotension (drop in DBP ≥ 10 mm Hg) | ||||||
| M1 | 1.78 (1.22, 2.58) | 0.003 | 1.14 (0.82, 1.59) | 0.44 | 1.16 (0.55, 2.46) | 0.70 |
| M2 | 1.27 (0.79, 2.02) | 0.32 | 1.19 (0.81, 1.74) | 0.38 | 2.07 (1.06, 4.07) | 0.03 |
| M3 | 1.21 (0.75, 1.97) | 0.43 | 0.76 (0.49, 1.16) | 0.20 | 1.59 (0.74, 3.41) | 0.24 |
| Ave | 1.33 (0.77, 2.28) | 0.30 | 1.05 (0.65, 1.68) | 0.85 | 1.13 (0.39, 3.27) | 0.82 |
| Min | 1.38 (0.99, 1.92) | 0.06 | 1.07 (0.82, 1.39) | 0.63 | 1.37 (0.79, 2.36) | 0.26 |
| Consensus orthostatic hypotension (drop in SBP ≥ 20 mm Hg or DBP ≥ 10 mm Hg) | ||||||
| M1 | 1.71 (1.27, 2.30) | 0.0004 | 1.22 (0.94, 1.58) | 0.14 | 1.16 (0.64, 2.12) | 0.63 |
| M2 | 1.73 (1.24, 2.41) | 0.001 | 1.30 (0.98, 1.73) | 0.07 | 2.52 (1.56, 4.08) | 0.0002 |
| M3 | 1.53 (1.09, 2.15) | 0.01 | 0.99 (0.74, 1.34) | 0.96 | 1.23 (0.65, 2.31) | 0.53 |
| Ave | 2.01 (1.41, 2.84) | 0.0001 | 1.22 (0.88, 1.70) | 0.24 | 1.62 (0.84, 3.10) | 0.15 |
| Min | 1.61 (1.25, 2.08) | 0.0003 | 1.16 (0.94, 1.43) | 0.18 | 1.50 (0.96, 2.35) | 0.07 |
Models were adjusted for baseline age, female, race, trial network, treatment arm, baseline SPB, baseline DBP, baseline heart rate, baseline body mass index, baseline fasting plasma glucose, history of cardiovascular disease, history of myocardial infarction, history of stroke, history of heart failure, and smoking status. All participants represented in this table had all 3 standing blood pressure measurements. These analyses included 4,267 participants for dizziness; 3,658 participants for fall; and 3,659 participants for fracture. Abbreviations: Ave, average; CI, confidence interval; DBP, diastolic blood pressure; Min, minimum; OR, odds ratio; SBP, systolic blood pressure.