Table 1.
Cytokine pairs classifying samples with incident syphilis
| Cytokine 1 | Cytokine 2 | Chi squared p-value | Association | Covers | Left-no | Left-yes | Right-no | Right-yes | Rate-left | Rate-right | Rel risk | Odds-left | Odds-right | Odds ratio | 95% CI |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EOTAXIN | RANTES | 0.006 | Pos | 26 | 2 | 9 | 12 | 3 | 0.82 | 0.20 | 4.09 | 4.50 | 0.25 | 18.00 | 2.47, 131.29 |
| IL27 | LEPTIN | 0.009 | Pos | 25 | 2 | 11 | 9 | 3 | 0.85 | 0.25 | 3.38 | 5.50 | 0.33 | 16.50 | 2.25, 121.23 |
| IL1RA | TRAIL | 0.012 | Pos | 37 | 11 | 7 | 3 | 16 | 0.39 | 0.84 | 0.46 | 0.64 | 5.33 | 0.12 | 0.03, 0.57 |
| IL1RA | MIG | 0.028 | Pos | 35 | 11 | 6 | 4 | 14 | 0.35 | 0.78 | 0.45 | 0.55 | 3.50 | 0.16 | 0.04, 0.69 |
| BDNF | MIG | 0.028 | Neg | 25 | 10 | 3 | 3 | 9 | 0.23 | 0.75 | 0.31 | 0.30 | 3.00 | 0.10 | 0.02, 0.63 |
| EOTAXIN | VCAM1 | 0.029 | Pos | 32 | 6 | 12 | 11 | 3 | 0.67 | 0.21 | 3.11 | 2.00 | 0.27 | 7.33 | 1.47, 36.67 |
| FASL | LEPTIN | 0.031 | Pos | 25 | 3 | 11 | 8 | 3 | 0.79 | 0.27 | 2.88 | 3.67 | 0.38 | 9.78 | 1.55, 61.65 |
| LEPTIN | MCP1 | 0.034 | Pos | 23 | 3 | 12 | 6 | 2 | 0.80 | 0.25 | 3.20 | 4.00 | 0.33 | 12.00 | 1.56, 92.29 |
| CD40L | IL22 | 0.037 | Pos | 25 | 7 | 8 | 0 | 10 | 0.53 | 1.00 | 0.53 | 1.13 | 21.00 | 0.05* | 0.003, 1.09 |
| EOTAXIN | VEGFD | 0.038 | Pos | 23 | 1 | 9 | 8 | 5 | 0.90 | 0.38 | 2.34 | 9.00 | 0.63 | 14.40 | 1.38, 150.81 |
| EOTAXIN | SCF | 0.038 | Pos | 29 | 5 | 11 | 10 | 3 | 0.69 | 0.23 | 2.98 | 2.20 | 0.30 | 7.33 | 1.38. 38.88 |
| LEPTIN | TNFB | 0.038 | Pos | 29 | 5 | 11 | 10 | 3 | 0.69 | 0.23 | 2.98 | 2.20 | 0.30 | 7.33 | 1.38. 38.88 |
| ENA78 | MIG | 0.038 | Neg | 24 | 10 | 2 | 4 | 8 | 0.17 | 0.67 | 0.25 | 0.20 | 2.00 | 0.10 | 0.01, 0.69 |
| IL6 | LEPTIN | 0.040 | Pos | 26 | 5 | 10 | 9 | 2 | 0.67 | 0.18 | 3.67 | 2.00 | 0.22 | 9.00 | 1.39, 58.45 |
| LEPTIN | RANTES | 0.041 | Pos | 31 | 3 | 11 | 11 | 6 | 0.79 | 0.35 | 2.23 | 3.67 | 0.55 | 6.72 | 1.33, 33.91 |
| IFNB | TRAIL | 0.041 | Pos | 34 | 11 | 9 | 2 | 12 | 0.45 | 0.86 | 0.53 | 0.82 | 6.00 | 0.14 | 0.02, 0.78 |
| EGF | MIG | 0.041 | Neg | 29 | 12 | 5 | 3 | 9 | 0.29 | 0.75 | 0.39 | 0.42 | 3.00 | 0.14 | 0.03, 0.74 |
| CD40L | TRAIL | 0.044 | Pos | 26 | 8 | 5 | 2 | 11 | 0.38 | 0.85 | 0.45 | 0.63 | 5.50 | 0.11 | 0.02, 0.74 |
| IFNG | IL1RA | 0.045 | Pos | 36 | 9 | 8 | 3 | 16 | 0.47 | 0.84 | 0.56 | 0.89 | 5.33 | 0.17 | 0.04, 0.79 |
| IL12P40 | IL12P70 | 0.048 | Pos | 32 | 9 | 8 | 2 | 13 | 0.47 | 0.87 | 0.54 | 0.89 | 6.50 | 0.14 | 0.02, 0.80 |
* This table lists all pairs of cytokines for which the ratio of uninfected to infected samples is significantly different (Chi square p-value < 0.05) between the most common extreme tertiles [e.g., either low:low vs. high:high (positive association), or low:high vs high:low (negative association)]. The Chi square p-value is also provided, as well as the counts of uninfected (no) and infected (yes) samples in each corner. Corners are referred to as “Left” or “Right”, which generalizes to both positive and negative slopes. Pairs are ordered by p-value. The number of samples contained in the relevant extrema is shown in the “covers” column. This is the sum of the left-no, left-yes, right-no, and right-yes columns. Relative risk and odds ratios are also included. These calculations compare frequencies of incident syphilis in the left corner to those in the right corner. In some cases, the left corner has a higher frequency of incident syphilis than does the right corner, while in other cases the right corner has a higher frequency. These patterns are reflected in the relative risk and odds ratios. Odds ratio for CD40L-IL22 was computed using the Haldane–Anscombe correction to account for a zero in one cell