Table 1.
Characteristics of included studies
| Author and publication year | Years recruiting | Study type | Country | N centres | Centre type | Inc. criteria | n | Male sex | Age | HIV infected | Median CD4 μL− 1 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Jacob et al. 2009 [5] | 2006 | Cohort | Uganda | 2 | Referral | SII severe sepsis | 382 | 156/382 (41%) | 35 | 320/382 (85%) | 52 |
| Nadjm et al. 2012 [25] | 2007 | Cohort | Tanzania | 1 | District | Fever and one severity criteria | 198 | 67/198 (34%) | 37 | 69/180 (38%) | NR |
| Jacob et al. 2012 [34]a and Moore et al. 2018 [23] | 2008–2009 | Before-after | Uganda | 2 | Referral | SII severe sepsis | 426 | 207/426 (49%) | 34 | 362/426 (85%) | 63 |
| Waitt et al. 2015 [26] | 2008–2009 | Cohort | Malawi | 1 | Referral | SII sepsis | 213 | 87/213 (41%) | 30 | 161/213 (76%) | NR |
| Ssekitoleko et al. 2011 [27]a | 2009 | Cohort | Uganda | 1 | Referral | SII sepsis | 96 | 193/418b (46%) | 35 | 331/418b (83%) | NR |
| Ssekitoleko et al. 2011 [28] | 2009 | Cohort | Uganda | 1 | Referral | SII sepsis | 150 | 94/150 (63%) | 35 | 96/150 (64%) | NR |
| Chimese et al. 2012 [21] | 2010 | Cohort | Zambia | 1 | Referral | SII sepsis | 161 | 79/161 (49%) | 39 | 110/138 (80%) | NR |
| Andrews et al. 2014 [35] | 2012 | RCT | Zambia | 1 | Referral | SII severe sepsis | 112 | 58/109 (53%) | 35 | 88/109 (81%) | NR |
| Auma et al. 2013 [29] | 2012 | Cohort | Uganda | 1 | Referral | SII sepsis | 216 | 106/216 (49%) | 32 | 122/216 (56%) | NRe |
| Andrews et al. 2017 [33] | 2012–2013 | RCT | Zambia | 1 | Referral | SII severe sepsis | 209 | 117/209 (56%) | 36 | 187/209 (90%) | 66 |
| Huson et al. 2014 [20] | 2012–2013 | Cohort | Gabon | 1 | Referral | SII sepsis | 107 | NA | 34 | 26/107 (24%) | 168 |
| Seboxa et al. 2015 [30] | 2012–2013 | Cohort | Ethiopia | 1 | Referral | SII sepsis | 292 | 151/292 (52%) | 27 | 40/209 (19%) | NR |
| Rudd et al. 2017 [31] | 2013 | Cohort | Uganda | 1 | District | SII sepsis | 20 | 11/20 (55%) | 32 | 6/20 (30%) | NR |
| Amir et al. 2016 [24] | 2014–2015 | Cohort | Uganda | 1 | Referral | SII severe sepsis | 218 | 110/218 (50%) | 35 | 125/218 (57%) | 78 |
RCT randomised controlled trial, SII Sepsis-2 definition (e.g. SII sepsis is consistent with Sepsis-2 definition). aThese studies also present data from Jacob et al. [5]—only new data is included in this table row. bDisaggregated data are not given for the included 96 patients; HIV prevalence for the total cohort is shown