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. 2019 Jun 10;17:194. doi: 10.1186/s12967-019-1942-z

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — a Western Blot. E4 + ECs scrambled and SH for jagged 1 were done and western blot analysis was performed to confirm the silencing of jagged 1 in E4 + ECs Sh jagged 1. b Volcano plot showing the fold change and FDR values for all genes. Significant genes are those with an FDR values ≤ 0.05 and are indicated in red. c Top 10 most significant pathways identified by Reactome. d Hierarchical clustering of cell cycle genes merged from different pathways for each replicate of E and EJ. Values displayed are normalized CPM