Table 2.
Results of overall and subgroup analyses
| Polymorphisms | Population | Sample size | Dominant comparison | Recessive comparison | Over-dominant comparison | Allele comparison | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases/ Controls | P value | OR (95%CI) | I2 | P value | OR (95%CI) | I2 | P value | OR (95%CI) | I2 | P value | OR (95%CI) | I2 | ||
| LEPR rs1137100 | Overall | 798/1841 | 0.80 | 0.91 (0.43–1.92) | 76% | 0.42 | 1.08 (0.90–1.29) | 0% | 0.64 | 0.96 (0.80–1.15) | 4% | 0.35 | 0.93 (0.81–1.08) | 31% |
| Caucasian | 377/1291 | 0.85 | 0.88 (0.24–3.20) | 88% | 0.75 | 1.04 (0.82–1.32) | 0% | 0.93 | 1.01 (0.80–1.28) | 37% | 0.74 | 0.95 (0.70–1.29) | 65% | |
| LEPR rs1137101 | Overall | 1235/2156 | 0.17 | 0.76 (0.52–1.13) | 81% | 0.62 | 1.12 (0.72–1.72) | 73% | 0.49 | 1.09 (0.86–1.38) | 53% | 0.31 | 0.85 (0.63–1.16) | 85% |
| East Asian | 621/650 | 0.61 | 0.70 (0.18–2.76) | 95% | 0.80 | 1.19 (0.31–4.61) | 89% | 0.94 | 0.98 (0.58–1.66) | 71% | 0.67 | 0.79 (0.27–2.32) | 96% | |
| South Asian | 236/210 | 0.10 | 0.72 (0.49–1.06) | 46% | 0.92 | 1.07 (0.29–3.99) | 87% | 0.06 | 1.46 (0.99–2.16) | 44% | 0.62 | 0.83 (0.39–1.75) | 86% | |
| Caucasian | 378/1296 | 0.31 | 0.87 (0.67–1.13) | 0% | 0.44 | 1.12 (0.84–1.50) | 0% | 0.76 | 1.04 (0.82–1.31) | 5% | 0.27 | 0.91 (0.77–1.08) | 0% | |
| MI | 306/494 | 0.27 | 0.71 (0.39–1.30) | 60% | 0.05 | 1.39 (0.99–1.94) | 40% | 0.73 | 0.95 (0.71–1.27) | 0% | 0.18 | 0.73 (0.47–1.15) | 70% | |
| LEP rs7799039 | Overall | 1136/989 | 0.27 | 0.78 (0.50–1.21) | 82% | 0.38 | 0.77 (0.43–1.38) | 78% | 0.0007 | 1.36 (1.14–1.63) | 41% | 0.67 | 0.92 (0.64–1.34) | 87% |
| East Asian | 754/445 | 0.46 | 0.76 (0.36–1.59) | 89% | 0.50 | 0.70 (0.25–1.96) | 86% | 0.04 | 1.50 (1.02–2.20) | 59% | 0.79 | 0.92 (0.48–1.75) | 92% | |
The values in bold represent statistically significant differences between cases and controls. Abbreviation: MI, myocardial infarction.