Table 1.
Clearance parameters for post-treatment dynamics of LDH, Aldo, and HRP2 proteins from P. falciparum-infected children in Angola
| LDH | Aldo | HRP2 | |
|---|---|---|---|
| Day 0 concentration (pg/ml), median (IQR) | 555,255 (219,090–1,803,141) | 35,758 (12,378–73,830) | 699,256 (287,765–1,429,700) |
| Day 2 concentration (pg/ml), median (IQR)a | 2559 (472–15,766) | 1168 (594–2975) | 421,035 (165,200–874,968) |
| Reduction from Day 0 to Day 2 (%), median (95% CI)a | 99.7 (99.5–99.8) | 96.32 (95.81–96.82) | 54.63 (44.65–62.61) |
| Decay rate pre-Day 2 (λ1), d−1, median (95% CI)a | 2.8 (2.6–3.0) | 1.7 (1.6–1.7) | 0.4 (0.30–0.49) |
| Decay rate post-Day 2 (λ2), d−1, median (95% CI)a | 0.38 (0.31–0.45) | 0.21 (0.20–0.23) | 0.15 (0.14–0.15) |
| Variation in concentration (σ), median (95% CI)a | 1.83 (1.83–1.83) | 1.02 (0.94–1.13) | 1.3 (1.2–1.3) |
| Half-life post-Day 2 (d), median (95% CI)a | 1.8 (1.5–2.3) | 3.2 (3.0–3.4) | 4.8 (4.7–4.9) |
Abbreviations: IQR: interquartile range; CI: credible interval; LDH: lactate dehydrogenase; Aldo: Aldolase; HRP2: histidine-rich protein 2; d: day
aEstimates calculated using observed and imputed values