. 2019 Jun 10;19:508. doi: 10.1186/s12879-019-4093-1

Table 3.

MIC distribution of eravacycline and relevant antibiotics against K. pneumoniae of different resistance characteristics

Antibiotics	Sensitive, n=10			ESBL, n=10			kpc-2 positive, n=9			NDM-1 positive, n=3			mcr-1 positive, n=4			Tigecycline resistant, n=13
Antibiotics	MIC₅₀	MIC₉₀	Range	MIC₅₀	MIC₉₀	Range	MIC₅₀	MIC₉₀	Range	MIC₅₀	MIC₉₀	Range	MIC₅₀	MIC₉₀	Range	MIC₅₀	MIC₉₀	Range
Eravacycline	0.25	0.5	0.125-0.5	0.5	1	0.125-2	0.5	2	0.25-4	0.5	1	0.5-1	1	16	0.5-16	8	16	2-16
Tigecycline	0.5	1	0.5-2	1	4	0.5-4	1	4	0.125	1	2	1--2	16	16	2-16	8	16	8-16
Piperacillin/Tazobactam	2	4	2-4	4	256	2-256	256	256	256-256	256	256	256-256	4	4	4-4	16	32	4-32
Cefoxitin	4	8	2-16	8	16	2-32	256	256	64-256	256	256	256-256	8	8	2-8	32	64	8-128
Ceftazidime	0.125	0.25	0.125-0.25	64	256	16-256	64	256	32-256	256	256	256-256	1	1	0.125-1	1	64	0.5-64
Cefoperazone/Sulbactam	0.25	0.25	0.125-0.25	16	64	8-64	256	256	256-256	256	256	256-256	1	1	0.5-1	2	32	1-128
Ceftriaxone	0.064	0.064	0.032-0.125	256	256	64-256	256	256	16-256	256	256	256-256	0.064	0.125	0.032-0.125	0.25	256	0.064-256
Cefotaxime	0.032	0.125	0.032-0.125	256	256	64-256	256	256	32-256	256	256	256-256	0.125	0.125	0.032-0.125	0.5	128	0.125-256
Cefepime	0.032	0.064	0.032-0.064	32	64	4-128	64	256	32-256	128	256	128-256	2	2	0.032-2	2	64	0.125-64
Ertapenem	0.016	0.016	0.016-0.016	0.25	0.5	0.032-0.5	32	32	32-32	32	32	32-32	0.016	0.016	0.016-0.016	0.032	0.25	0.016-0.5
Imipenem	0.125	0.25	0.125-1	0.125	0.25	0.125-0.25	8	32	8-32	8	32	8-32	0.125	0.25	0.125-0.25	0.125	0.125	0.125-0.5
Meropenem	0.016	0.032	0.016-0.032	0.032	0.064	0.032-0.125	16	32	8-32	16	32	8-32	0.032	0.064	0.032-0.064	0.032	0.064	0.016-0.064
Colistin	0.25	0.25	0.125-0.25	0.25	0.25	0.125-0.25	0.25	0.25	0.125-0.25	0.25	0.25	0.125-0.25	32	64	16-64	0.25	32	0.125-32
Amikacin	1	1	0.5-1	1	4	0.5-32	1	256	0.5-256	2	2	1--2	1	1	1-1	1	2	0.5-256
Minocycline	2	4	2-8	16	32	2-32	32	32	4-32	32	32	4-32	16	32	16-32	32	128	16-256
Ciprofloxacin	0.016	0.032	0.016-0.25	2	64	0.016-64	32	64	16-64	64	64	64-64	32	32	0.032-32	32	64	0.25-64
Levofloxacin	0.064	0.125	0.064-0.5	2	16	0.064-64	16	64	16-64	32	32	16-32	16	16	0.064-16	8	32	0.5-64

^a: Sensitive strains referred to strains do not have ESBL, carbapenem resistance and polymyxin resistance