Table 6.
MIC distribution of Eravacycline and relevant antibiotics against Enterococci. spp of different resistance characteristics
Antibiotics | E.faecalis, n = 10 | E.faecium, n = 8 | VREa, n = 3 | ||||||
---|---|---|---|---|---|---|---|---|---|
MIC50 | MIC90 | Range | MIC50 | MIC90 | Range | MIC50 | MIC90 | Range | |
Eravacycline | 0.032 | 0.032 | 0.016–0.125 | 0.016 | 0.032 | 0.008–0.064 | 0.016 | 0.032 | 0.008–0.032 |
Tigecycline | 0.064 | 0.064 | 0.064–0.125 | 0.064 | 0.064 | 0.016–0.125 | 0.125 | 0.25 | 0.125–0.25 |
Ampicillin | 1 | 8 | 1–8 | 64 | 64 | 4–64 | 64 | 64 | 64–64 |
Vancomycin | 1 | 2 | 0.5–2 | 0.5 | 1 | 0.25–1 | 128 | 128 | 128–128 |
Teicoplanin | 0.125 | 0.25 | 0.032–0.25 | 0.25 | 0.25 | 0.064–0.25 | 32 | 64 | 32–64 |
Erythromycin | 1 | 256 | 0.25–256 | 256 | 256 | 0.016–256 | 0.125 | 256 | 0.125–256 |
Minocycline | 16 | 16 | 0.064–16 | 0.032 | 16 | 0.032–16 | 0.064 | 16 | 0.064–16 |
Ciprofloxacin | 2 | 32 | 0.5–64 | 64 | 64 | 4–64 | 64 | 64 | 64–64 |
Levofloxacin | 2 | 64 | 1–64 | 64 | 128 | 1–128 | 64 | 64 | 64–64 |
Linezolid | 1 | 2 | 1–2 | 1 | 1 | 0.5–1 | 1 | 1 | 1–1 |
a VRE referred to vancomycin-resistant Enterococci. All of the 3 VRE strains in this study were E.faecium