. 2019 Jun 10;19:508. doi: 10.1186/s12879-019-4093-1

Table 7.

MIC distribution of Eravacycline and relevant antibiotics against S.pneumoniae of different resistance characteristics

Antibiotics	PSSP^a, n = 10			PRSP^b, n = 10
Antibiotics	MIC₅₀	MIC₉₀	Range	MIC₅₀	MIC₉₀	Range
Eravacycline	0.008	0.008	0.002–0.016	0.008	0.008	0.004–0.008
Tigecycline	0.016	0.016	0.008–0.016	0.016	0.016	0.016–0.016
Penicillin	0.016	0.016	0.016–0.032	4	4	4–4
Amoxicillin/Clavulanic acid	0.016	0.064	0.008–0.25	8	8	8–8
Cefuroxime	0.032	0.125	0.016–0.5	16	32	8–32
Cefaclor	1	2	1–4	256	256	128–256
Ceftriaxone	0.032	0.064	0.016–0.125	2	8	1–8
Erythromycin	8	32	0.5–256	256	256	128–256
Azithromycin	16	32	4–256	256	256	256–256
Clindamycin	0.125	128	0.032–256	256	256	128–256
Clarithromycin	2	32	0.25–256	256	256	256–256
Levofloxacin	1	1	0.25–32	1	1	1–1
Moxifloxacin	0.125	0.125	0.064–16	0.125	0.25	0.125–0.25
Trimethoprim/Sulfamethoxazole	4	8	0.064–8	8	16	4–32
Tetracycline	32	64	4–64	32	32	32–32
Chloramphenicol	4	8	1–16	4	4	4–4
Vancomycin	0.25	0.25	0.125–0.25	0.25	0.25	0.25–0.25

^a PSSP Penicillin-sensitive Streptococcus pneumoniae

^b PRSP Penicillin-resistant Streptococcus pneumoniae