Table 8.
MIC distribution of Eravacycline and relevant antibiotics against H. influenza of different resistance characteristics
| Antibiotics | β-lactamases negative, n = 10 | β-lactamases positive, n = 10 | ||||
|---|---|---|---|---|---|---|
| MIC50 | MIC90 | Range | MIC50 | MIC90 | Range | |
| Eravacycline | 0.064 | 0.125 | 0.064–0.125 | 0.064 | 0.125 | 0.032–0.125 |
| Tigecycline | 0.25 | 0.5 | 0.125–0.5 | 0.125 | 0.25 | 0.064–0.5 |
| Ampicillin | 0.125 | 0.5 | 0.125–1 | 16 | 64 | 0.064–64 |
| Amoxicillin/Clavulanic acid | 0.125 | 0.5 | 0.125–0.5 | 1 | 1 | 0.5–1 |
| Penicillin | 16 | 32 | 0.032–32 | 16 | 32 | 1–64 |
| Cefaclor | 2 | 8 | 0.5–8 | 4 | 16 | 1–32 |
| Cefuroxime | 1 | 2 | 0.25–4 | 1 | 4 | 0.25–16 |
| Azithromycin | 1 | 4 | 0.064–4 | 2 | 64 | 0.25–64 |
| Clarithromycin | 4 | 16 | 0.5–16 | 4 | 64 | 1–64 |
| Levofloxacin | 0.032 | 1 | 0.016–1 | 0.032 | 0.125 | 0.016–0.5 |
| Moxifloxacin | 0.032 | 1 | 0.016–1 | 0.032 | 0.25 | 0.016–0.5 |
| Trimethoprim/Sulfamethoxazole | 16 | 32 | 0.032–32 | 16 | 32 | 1–64 |
| Tetracycline | 1 | 4 | 0.064–4 | 2 | 64 | 0.25–64 |
| Chloramphenicol | 0.5 | 1 | 0.25–1 | 1 | 8 | 0.5–8 |