Table 4.
Summary of CDSs annotated to antibiotic resistance between SO-1977, MRSA252 and MSSA476 strains
| No | SO-1977 | MRSA252 | MSSA476 | Seed subsystem | Seed function | Length (bp) | Contig number |
|---|---|---|---|---|---|---|---|
| 1 | ✓ | ✓ | Peptidoglycan Biosynthesis | Methicillin resistance determinant MecA, transpeptidase | 2007 | Contig 000034 | |
| 2 | ✓ | ✓ | ✓ | Multidrug Resistance, 2-protein version Found in Gram-positive bacteria | Multidrug resistance protein [function not yet clear] | 648 | Contig 000037 |
| 3 | ✓ | ✓ | ✓ | Multidrug Resistance, 2-protein version Found in Gram-positive bacteria | Membrane component of multidrug resistance system | 1932 | Contig 000037 |
| 4 | ✓ | ✓ | ✓ | Multidrug Resistance, 2-protein version Found in Gram-positive bacteria | TetR family regulatory protein of MDR cluster | 555 | Contig 000037 |
| 5 | ✓ | Tetracycline resistance, ribosome protection type | Tetracycline resistance protein TetM | 1920 | Contig 000042 | ||
| 6 | ✓ | Tetracycline resistance, ribosome protection type | Translation elongation factor G | 2082 | Contig 000014 | ||
| 7 | ✓ | ✓ | ✓ | Teicoplanin-resistance in Staphylococcus | Teicoplanin resistance associated membrane protein TcaA | 1209 | Contig 000002 |
| 8 | ✓ | ✓ | ✓ | Teicoplanin-resistance in Staphylococcus | Teicoplanin resistance associated membrane protein TcaB | 1383 | Contig 000002 |
| 9 | ✓ | ✓ | ✓ | Teicoplanin-resistance in Staphylococcus | Teicoplanin-resistance associated HTH-type transcriptional regulator TcaR | 456 | Contig 000002 |
| 10 | ✓ | Quinolone resistance protein norA | none | 1167 | Contig 000007 | ||
| 11 | ✓ | ✓ | Bicyclomycin resistance protein TcaB | none | 1212 | Contig 000002 | |
| 12 | ✓ | ✓ | ✓ | Transcriptional regulator, MarR family | None | 456 | Contig 000003 |
| 13 | ✓ | ✓ | ✓ | Transcriptional regulator, MarR family | None | 420 | Contig 000005 |
| 14 | ✓ | ✓ | ✓ | Transcriptional regulator, MarR family | None | 210 | Contig 000043 |
| 15 | ✓ | ✓ | ✓ | Transcriptional regulator, MarR family | None | 435 | Contig 000030 |
| 16 | ✓ | ✓ | ✓ | Transcriptional regulator, MarR family | None | 441 | Contig 000001 |
| 17 | ✓ | ✓ | ✓ | Transcriptional regulator,MarR family | None | 468 | Contig 000030 |
| 18 | ✓ | ✓ | ✓ | Resistance to fluoroquinolones | DNA gyrase subunit B | 2403 | Contig 000010 |
| 19 | ✓ | ✓ | ✓ | Resistance to fluoroquinolones | DNA gyrase subunit A | 2661 | Contig 000011 |
| 20 | ✓ | ✓ | ✓ | Resistance to fluoroquinolones | Topoisomerase IV subunit B | 1998 | Contig 000010 |
| 21 | ✓ | ✓ | ✓ | Resistance to fluoroquinolones | Topoisomerase IV subunit A | 2403 | Contig 000010 |
| 22 | ✓ | ✓ | ✓ | Beta-lactamase | Beta-lactamase | 1500 | Contig 000002 |
| 23 | ✓ | ✓ | ✓ | Beta-lactamase | Beta-lactamase repressor BlaI | 381 | Contig 000067 |
| 24 | ✓ | ✓ | ✓ | Multidrug Resistance Efflux Pumps | Acriflavin resistance protein | 3168 | Contig 000001 |
| 25 | ✓ | ✓ | ✓ | Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps | Multidrug Resistance Efflux Pumps | 1356 | Contig 000005 |
| 26 | ✓ | ✓ | Methicillin resistance in staphylococci | HmrB protein involved in methicillin resistance | 1600 | NC_002952 | |
| 27 | ✓ | ✓ | ✓ | Methicillin resistance in staphylococci | Beta-lactamase repressor BlaI | 381 | Contig 000067 |
| 28 | ✓ | ✓ | ✓ | Methicillin resistance in staphylococci | FmhA protein of FemAB family | 1251 | Contig 000002 |
| 29 | ✓ | Methicillin resistance in staphylococci | LytH protein involved in methicillin resistance | 1600 | NC_002952 | ||
| 30 | ✓ | ✓ | Methicillin resistance in staphylococci | Methicillin resistance regulatory sensor-transducer MecR1 | 1600 | Contig 000034/ NC_002952 | |
| 31 | ✓ | Methicillin resistance in staphylococci | Methicillin resistance repressor MecI | 1600 | NC_002952 | ||
| 32 | ✓ | Methicillin resistance in staphylococci | Transposase for insertion sequence-like element IS431mec | 1296 | NC_002952 | ||
| 33 | ✓ | Methicillin resistance in staphylococci | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase | 1600 | NC_002952 | ||
| 34 | ✓ | ✓ | ✓ | Methicillin resistance in staphylococci | Beta-lactamase regulatory sensor-transducer BlaR1 | 1089 | Contig 000067 |