Table 3.

Association of exposure to severe famine with CpG1 site of the IGF2 gene among GRECF study participants

		Age- and sex-adjusted model*		Pinteraction†	Fully adjusted model**		Pinteraction§
Methylation		Beta( SE)	P		Beta( SE)	P
Overall	Overall	0.005 (0.01)	0.70	0.89	0.004 (0.01)	0.75	0.91
	Male	0.005 (0.02)	0.78		0.003 (0.02)	0.87
	Female	0.006 (0.02)	0.76		0.003 (0.02)	0.88
CpG1 site	Overall	0.07 (0.02)	0.0008	0.18	0.07 (0.02)	0.002	0.15
	Male	0.04 (0.02)	0.09		0.03 (0.03)	0.24
	Female	0.10 (0.03)	0.004		0.10 (0.04)	0.008
CpG2 site	Overall	− 0.01 (0.02)	0.82	0.56	− 0.01 (0.03)	0.78	0.73
	Male	0.005 (0.03)	0.88		− 0.002 (0.04)	0.95
	Female	− 0.01(0.04)	0.72		− 0.008 (0.04)	0.84
CpG3 site	Overall	0.02 (0.02)	0.42	0.08	0.02 (0.02)	0.41	0.07
	Male	0.05 (0.03)	0.04		0.06 (0.03)	0.03
	Female	− 0.02 (0.03)	0.54		− 0.02 (0.03)	0.45
CpG4 site	Overall	− 0.02 (0.02)	0.27	0.71	− 0.02 (0.02)	0.24	0.52
	Male	− 0.01 (0.02)	0.54		− 0.01 (0.02)	0.63
	Female	− 0.03 (0.03)	0.36		− 0.04 (0.03)	0.22
CpG5 site	Overall	0.01 (0.01)	0.24	0.64	0.01 (0.01)	0.29	0.83
	Male	0.008 (0.01)	0.33		0.005 (0.01)	0.53
	Female	0.007 (0.01)	0.47		0.01 (0.01)	0.33
CpG6 and CpG7 site	Overall	− 0.02 (0.01)	0.13	0.24	− 0.02 (0.01)	0.15	0.38
	Male	− 0.004 (0.02)	0.78		− 0.002 (0.02)	0.91
	Female	− 0.04 (0.02)	0.11		− 0.04 (0.02)	0.12
CpG8 site	Overall	− 0.02 (0.02)	0.44	0.56	− 0.02 (0.02)	0.27	0.75
	Male	− 0.005 (0.02)	0.83		− 0.019 (0.02)	0.41
	Female	− 0.03 (0.03)	0.43		− 0.04 (0.03)	0.26

SE standard error

*Adjusted for age and sex among the overall sample; adjusted for age among male and female, respectively

^†Assessed by adding an interaction term, gender × famine severity to the age- and sex-adjusted model among the overall participants

**Adjusted for age, sex, smoking, drinking, and education level among the overall sample

^§Assessed by adding an interaction term, gender × famine severity to the fully adjusted model among the overall participants