Fig. 1.

Antitumor effects of NHS-muIL12 on MB49^luc bladder tumors. a NHS-muIL12 treatment (days 9, 12 and 15) and analyses (days 18, 21) schedule of mice bearing MB49^luc bladder tumors. b Representative in vivo luciferase expression images taken immediately prior to euthanasia at days 6, 18, 21, and 32 for control Ig– (top row) and NHS-muIL12–treated mice (bottom row). c Individual bladder weights from control Ig–treated (circles, triangles) and NHS-muIL12–treated (squares, inverted triangles) mice at 72 and 144 h post–final NHS-muIL12 injection (days 18 and 21). Horizontal lines represent the average bladder weight; error bars represent mean ± SEM, Student’s t-test; *P < 0.05. Data are from a representative experiment that was repeated with similar results