Table 2.
Lung cancer incidence per 10,000 person-years by age in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) and interstitial lung disease (ILD)-only
| CTD-ILD | ILD-only | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age (years) | Population (n) | Lung cancer cases (n) | Person-years of follow-up | Incidence | Population (n) | Lung cancer cases (n) | Person-years of follow-up | Incidence | RR | 95% CI | P value | E value |
| 40–49 | 472 | 19 | 2054.3 | 92.5 | 1667 | 28 | 6924.3 | 40.4 | 2.28 | 1.20–4.24 | 0.01 | 3.60 (1.00-NA) |
| 50–59 | 685 | 40 | 2873.7 | 139.2 | 2679 | 95 | 11,109.3 | 85.5 | 1.62 | 1.09–2.38 | 0.01 | 2.87 (1.43-NA) |
| 60–69 | 753 | 59 | 2988.0 | 197.5 | 3535 | 220 | 14,041.9 | 156.7 | 1.26 | 0.92–1.68 | 0.13 | |
| 70–79 | 493 | 41 | 1768.7 | 231.8 | 3446 | 258 | 12,371.2 | 208.5 | 1.11 | 0.77–1.55 | 0.57 | |
| > 80 | 88 | 6 | 271.4 | 221.1 | 1460 | 96 | 4232.2 | 226.8 | 0.97 | 0.34–2.20 | 1.00 | |
| Total | 2491 | 165 | 9956.1 | 165.7 | 12,787 | 697 | 48,679.0 | 143.2 | 1.15 | 0.97–1.37 | 0.10 | |
RR, rate ratio; CI, confidence interval; NA, not available; E value was calculated by VanderWeele and Ding method [29]