Table 2.

Clinical characteristics and diagnostic latency classified by the initially presenting motor phenotype

	Rest tremor (n = 65) A	Limb rigidity (n = 32) B	Walking problems (n = 15) C	Movement slowness (n = 19) D	P	Post hoc significance
UPDRS-III score※,b	8 (6,11)	21 (18,24)	36 (29,41)	27 (23,38)	< 0.001	A < B**, A < C**, A < D**, B < C**, B < D**, D < C*
H&Y grade#, a					/	/
(0~1]	42 (64.6%)	0	0	0
(1~2]	23 (35.4%)	32 (100%)	9 (60.0%)	17 (89.5%)
> 2	0	0	6 (40.0%)	2 (10.5%)
NMSquest score※,b	3 (2,6)	7 (4,10)	8 (4,10)	9 (6,13)	0.001	A < B**, A < C**, A < D**, B < D**
HAMA score※,b	5 (2,8)	8 (5,11)	13 (8,15)	6 (4,10)	0.002	A < B**, A < C**, A < D*, B < C*, D < C**
HAMD score※,b	5 (2,10)	10 (6,12)	18 (12,21)	11 (5,18)	< 0.001	A < B*, A < C**, A < D**, B < C**, D < C**
MMSE score※,b	28 (26,30)	29 (26,30)	26 (25,28)	28 (27,30)	< 0.001	C < A**, C < B**, C < D**
Time A※,b (months)	4 (2,6)	10 (5,12)	6 (5,10)	16 (11, 21)	< 0.001	A < B**, A < C**, A < D** B < D**, C < D**
Time B※,b (months)	6 (4,7)	11 (9,18)	16 (12,18)	8 (6.5, 15)	< 0.001	A < B**, A < C**, A < D**, B < C*, D < B**, D < C**
Time C※,b (months)	10 (7,12)	22 (17,27)	24 (20,27)	27 (23.5, 31)	< 0.001	A < B**, A < C**, A < D**,

^#results were presented as percentage

^※results were presented as presented as medians (quarters)

^aanalyzed by χ² test

^banalyzed by by Nemenyi test; * = p < 0.05; ** = p < 0.01; Bold values indicated statistically significant values; UPDRS = Unified Parkinson Disease

Rating Scale; H&Y grade = Hoehn &Yahr grade; NMSquest = Non-motor symptoms questionnaire; HAMA = Hamilton Anxiety

Scale; HAMD = Hamilton Depression Scale; MMSE: Mini mental State Exam; Time A = the time from motor symptom onset to patients’ initiation of medical consultations; Time B = the time from patients’ first medical consultations to PD diagnosis; Time C = the time from motor symptom onset to clinical diagnosis of Parkinson’s disease