Table 4.

Determinants of the targeted time intervals in the multivariate COX model

Variables	HR	95%CI	p
Time C
Initially presenting motor phenotype
Limb stiffness vs rest tremor	0.168	0.081~0.347	< 0.001**
Walking problems vs rest tremor	0.717	0.223~2.309	0.578
Movement slowness vs rest tremor	0.419	0.151~1.167	0.096
NMSquest score	0.871	0.815~0.930	< 0.001**
UPDRS motor score	0.916	0.883~0.950	< 0.001**
HAMA score	0.965	0.901~1.034	0.312
HAMD score	1.049	0.993~1.107	0.087
The first medical consultation with physicians or specialists of non-neurology	0.346	0.198~0.606	< 0.001**

** = p < 0.01

HR = hazard ratio; CI = confidence interval; Bold values indicated statistically significant values; UPDRS = Unified Parkinson Disease Rating Scale; NMSquest = Non-motor symptoms questionnaire; HAMA = Hamilton Anxiety Scale; HAMD = Hamilton Depression Scale; Time A = the time from motor symptom onset to patients’ initiation of medical consultations; Time B = the time from patients’ first medical consultation to PD diagnosis; Time C = the time from motor symptom onset to clinical diagnosis of Parkinson’s disease