Treatment with D2 antagonists affects many vital metabolic processes within cancer cells and tumors. Cancer stem cell-like activities, survival signaling, and proliferation are reduced by treatment. However, intracellular calcium levels, autophagy, and apoptosis are increased. Additionally, lipid synthesis and trafficking are disrupted. The direct mechanisms by which these alterations occur is not currently known, but these compounds may ultimately lead to cell death through these or other pathways.