TABLE 3.

Ligand affinities of select D₂ antagonists, agonists, and functionally selective ligands (nM)¹

Compound	D2	Reference Ligand	Source	D1	Reference Ligand	Source	D3	Reference Ligand	Source	D4	Reference Ligand	Soursce	D5	Reference Ligand	Source
Aripiprazole	0.59	3H-NMSP	Lawler et al. (1999)	410	3H-SCH23390	Lawler et al. (1999)	9.7	3H-NMSP	Shapiro et al. (2003)	514	3H-NMSP	Besnard et al. (2012)	1200	3H -SCH23390	Lawler et al. (1999)
Chlorpromazine	2	3H-NMSP	Besnard et al. (2012)	112	3H-SCH23390	Besnard et al. (2012)	1.3	3H-raclopride	Seeman (1995)	24	3H-NMSP	Besnard et al. (2012)	133	3H -SCH23390	Besnard et al. (2012)
Clomipramine	77.6	3H-spiperone	Millan et al. (2001)	219	3H-SCH23390	Toll et al. (1998)	50.1	3H-spiperone	Millan et al. (2001)
Clozapine	431	3H-NMSP	Besnard et al. (2012)	189	3H-SCH23390	Besnard et al. (2012)	340	3H-nemonapride	Seeman (1995)	39	3H-NMSP	Besnard et al. (2012)	235	3H -SCH23390	Besnard et al. (2012)
Fluphenazine	0.54	3H-NMSP	Besnard et al. (2012)	24	3H-SCH23390	Besnard et al. (2012)	0.3	3H-nemonapride	Seeman (1995)	36	3H-NMSP	Besnard et al. (2012)	12	3H -SCH23390	Besnard et al. (2012)
Haloperidol	2	3H-NMSP	Besnard et al. (2012)	83	3H-SCH23390	Besnard et al. (2012)	23	3H-nemonapride	Seeman (1995)	15	3H-NMSP	Besnard et al. (2012)	147	3H-SCH23390	Besnard et al. (2012)
Olanzapine	72	3H-NMSP	Besnard et al. (2012)	58	3H-SCH23390	Besnard et al. (2012)	40	3H-nemonipride	Seeman (1995)	19	3H-NMSP	Besnard et al. (2012)	90	3H-SCH23390	Besnard et al. (2012)
Penfluridol	5.6	3H-haloperidol	Burt et al. (1976)	1600*	3H-dopamine	Burt et al. (1976)				31**	3H-spiperone	Roth et al. (1995)
Perphenazine	1.4	3H-NMSP	Burt et al. (1976), Kroeze et al. (2003)	29.9**	3H-SCH23390	Billard et al. (1984)	1.1	3H-nemonapride	Seeman (1995)	32	3H-spiperone	Seeman (1995)
Pimozide	0.65	3H-NMSP	Kroeze et al. (2003)	>104	3H-SCH23390	Toll et al. (1998)	11	125I-iodosulpride	Schmidt et al. (1992)	1.8	R-SAT	Burstein et al. (2005)
Prochlorperazine	4	3H-spiperone	Seeman (1995)				1.8	125I-iodosulpride	Schmidt et al. (1992)	70	3H-spiperone	Seeman (1995)
Risperidone	4.9	3H-NMSP	Besnard et al. (2012)	60.6	3H-SCH23390	Besnard et al. (2012)	5.2	3H-nemonapride	Seeman (1995)	18.6	3H-NMSP	Besnard et al. (2012)	16	3H-SCH23390	Besnard et al. (2012)
SCH 23390	2145	3H-domperidone	Grandy et al. (1989)	0.35	3H-SCH23390	Sunahara et al. (1991)	>10,000	3H-nemonapride	Neumeyer et al. (2003)	3560	3H-spiperone	Van Tol et al. (1991)	0.3	3H-SCH23390	Sunahara et al. (1991)
Spiperone	0.125	3H-domperidone	Grandy et al. (1989)	577	3H-SCH23390	Sunahara et al. (1991), Toll et al. (1998)	0.275	3H-spiperone	Cussac et al. (2000), Neumeyer et al. (2003)	4	3H-spiperone	Tang et al. (1994)	4500	3H-SCH23390	Sunahara et al. (1991)
Thioridazine	10	3H-NMSP	Grandy et al. (1989), Besnard et al. (2012)	89	3H-SCH23390	Besnard et al. (2012)	5.2	3H-spiperone	Seeman (1995)	17	3H-NMSP	Besnard et al. (2012)	216	3H-SCH23390	Besnard et al. (2012)
Trifluoperazine	1.3	3H-NMSP	Kroeze et al. (2003)	740*	3H-dopamine	Burt et al. (1976)				44	3H-spiperone	Seeman et al. (1997), Besnard et al. (2012)

Unmarked, human receptor. *, calf receptor. **, rat receptor.

¹Most values and references from the PDSP K_I database (https://pdsp.unc.edu/databases/pdsp.php) except for Seeman (1995) and Lawler et al. (1999).