Fig. 3.

Bexarotene-induced decrease in HP levels of soluble Aβ 40 and 42 requires ABCA1. ABCA1 WT and KO mice were crossed with APP/ PS1 mice (females; 10 months). Mice were treated with bexarotene (100 mg/kg/day p.o.) or vehicle for 7 days. Following drug treatment, mice were sacrificed and hippocampus (HP) was dissected from the right hemisphere of the brain. HP was homogenized and levels of soluble and insoluble Aβ40 and 42 were measured by ELISA. a and b show levels of soluble Aβ40 and 42, respectively. c and d show levels of insoluble Aβ40 and 42, respectively. Bars represent the mean ± SEM of each group expressed as a relative percent of ABCA1 WT vehicle-treated mice (n=10–12). Two way ANOVA analysis with Bonferroni posttest was performed. # indicates significant main effect of ABCA1 genotype, # p<0.05, ## p<0.01, ### p<0.001. * indicates significant difference in Bonferonni post-hoc test, * p<0.05