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. 2019 May 30;25:4014–4024. doi: 10.12659/MSM.916508

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© Med Sci Monit, 2019

This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

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Neuromedin U (NmU) was highly expressed in colorectal cancer (CRC) and promoted migration and invasion of CRC cells. (A) Quantitative real-time polymerase chain reaction (qRT-PCR) shows neuromedin U (NmU) expression in 48 colorectal cancer (CRC) tissues was significantly higher than in normal controls. (B) The expression level of LINC01555 was highly correlated with NMU expression in colorectal cancer (CRC) tissues. (C) Protein expression of NmU was downregulated after LINC01555 knockdown in SW620 and HCT116 cells. (D) NmU expression was significantly inhibited, as detected by qRT-PCR. (E) The cell counting kit-8 (CCK-8) assay shows decreased cell viability. (F) The transwell assay shows decreased migratory ability. (G) The transwell assay shows decreased invasive ability. NMU: neuromedin U.