Figure 2.

Phage titres in murine spleen and liver after administration of T4 phage presenting peptides targeting lungs (T4‐L1 and T4‐L2), prostate (T4‐P1 and T4‐P2), brain (T4‐B) and facilitating translocation from gut to circulation (T4‐G1 and T4‐G2). Mice (N = 5 to 6) were injected intraperitoneally with a phage dose of 5 × 10⁹ pfu per mouse (each phage) and phage titre was measured in tissues 2 h later (T4‐L1, T4‐L2, T4‐P1, T4‐P2, T4‐B) or phage was added to drinking water at 5 × 10¹⁰ pfu per ml and phage titre was measured 10 h later in blood (T4‐G1 and T4‐G2). In each case, non‐modified T4 phage (blue bars) was used as a control. Log₁₀ of mean phage concentrations in selected organs (pfu per gram of tissue or per ml of blood) is presented (bars) with standard deviation (whiskers). Differences statistically significant in comparison to control phage are indicated with asterisks and red colour of a relevant bar (Mann–Whitney U‐test, P < 0.05).