Table 2.

Characteristics of studies included in the qualitative synthesis (systematic review)

Authors and year of publication	Study design	Population (followed up participants)	Follow-up period	Intervention	Comparison	Outcome assessment method
Ammari et al., 2017	Split-mouth controlled randomized clinical trial	42 children (42 lesion pairs) Age range of children at baseline: 5-8 years old	6 and 12 months	Resin infiltration of NCPLs in primary molars Infiltrant: Icon®, (DMG, Hamburg, Germany)	Test group (fluoridated toothpaste + flossing + infiltration) Control group (fluoridated toothpaste + flossing)	Pairwise radiographic comparison of baseline and follow-up bitewing radiographs
Arthur et al., 2017	Double-blind split-mouth placebo-controlled randomized clinical trial	17 participants (27 lesion pairs) Age range at baseline: 16-41 years old	36 months	Resin infiltration of NCPLs Infiltrant: Icon® (DMG, Hamburg, Germany)	Placebo treatment	Pairwise radiographic comparison of baseline and follow-up bitewing radiographs
Ekstrand, Bakhshandeh and Martignon 2010	Split-mouth controlled randomized clinical trial	39 children	6 months and 12 months	Resin infiltration of NCPLs Infiltrant resin: Triethylene glycol dimethacrylate- based resin, camphorquinone, additives; DMG, Hamburg, Germany	Test lesion: resin infiltration followed by FV Control lesion: Only FV	Scoring caries progression in bitewing radiographs
Foster Page et al., 2017	Split-mouth placebo-controlled randomized controlled trial	69 children Age range at baseline: 7-9 years old	6, 12, and 24 months	Resin infiltration of NCPLs Infiltrant: DMG Icon preproduct	Test group (infiltration: DMG Icon preproduct and FV) Control group (FV)	Pairwise radiographic comparison of baseline and follow-up bitewing radiographs
Martignon et al., 2012	Split-mouth controlled randomized clinical trial	37 participants (each had at least 3 NCPLs) Age range at baseline: 16-35 years old	36 months (annual follow-up)	Resin infiltration of NCPLs Infiltrant: ICON® preproduct (DMG, Hamburg, Germany)	Test- A (Infiltration: ICON-preproduct; DMG) Test-B (Sealing: Prime-Bond NT; Dentsply) Control-C (Placebo)	Pairwise radiographic comparison of baseline and follow-up bitewing radiographs
Meyer-Lueckel, Bitter and Paris 2012	Split-mouth placebo-controlled randomized clinical trial	19 young adults (25 lesion pairs)	18 and 36 months	Resin infiltration of NCPLs Infiltrant: Icon, preproduct; DMG, Hamburg	Placebo treatment	Pairwise radiographic comparison and DSR of baseline and follow-up bitewing radiographs
Meyer-Lueckel et al., 2016	Split-mouth placebo-controlled randomized clinical trial	79 participants (218 lesion pairs) Age range at baseline: 17-29 years old	10 and 18 months	Resin infiltration of NCPLs Infiltrant: Icon; DMG, Hamburg, Germany	Placebo treatment	Pairwise radiographic comparison of baseline and follow-up bitewing radiographs

NCPLs=Noncavitated proximal lesion/s, FV=Fluoride varnish, DSR=Digital subtraction radiography, DMG=Dental milestones guaranteed company