Table 3.

Quality of evidence by the GRADE approach

Summary of findings:
Resin infiltration compared to Control/placebo for slowing/arresting caries progression rate
Patient or population: slowing/arresting caries progression rate Setting: Secondary care setting Intervention: Resin infiltration Comparison: Control/placebo
Outcomes	Anticipated absolute effects*(95% CI)		Relative effect (95% CI)	№ of participants (studies)	Certainty of the evidence (GRADE)	Comments
	Risk with Control/placebo	Risk with Resin infiltration
Caries progression rate in permanent teeth assessed with: Pairwise comparison follow up: range 18 months to 36 months	301 per 1,000	57 per 1,000 (33 to 99)	RR 0.19 (0.11 to 0.33)	478 (3 RCTs)	⊕⊕⊕⊕HIGH
Caries progression rate in primary teeth assessed with: Secondary care setting follow up: range 12 months to 24 months	436 per 1,000	209 per 1,000 (131 to 327)	RR 0.48 (0.30 to 0.75)	209 (2 RCTs)	⊕⊕⊕⊕HIGH

*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio. GRADE Working Group grades of evidence. High certainty: We are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect. Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect