Table 1.

Univariate and multivariste analyses of relationship between various clinicopathological factors and disease-free survival (DFS)

Variable	Factors	Number	Univariate			Multivariate
Recurrence(-)	Recurrence(+)	P-value	Hazard ratio	95%CI	P-value
Sex	Male	41	16	25	0.826
	Female	14	5	9
Age	<70	28	12	16	0.467
	≧70	27	9	18
BMI (kg/m2)	＜25	47	19	28	0.406
	≧25	8	2	6
Biliary tract	(+)	48	16	32	0.053
Decompression	(-)	7	5	2
Macroscopic	flat infiltrating	31	9	22	0.112
Type	others	24	12	12
Histological	tub1,pap	24	10	14	0.64
Type	others	31	11	20
Tumor size	<20	13	6	7	0.498
	≧20	42	15	27
T	1,2	15	10	5	0.008	1.659	0.690–3.991	0.258
	3	40	11	29
N	0	31	13	18	0.515
	1	24	8	16
M	53	53	21	32	0.258
	2	2	0	2
DLN	<13	25	10	15	0.8
	≧13	30	11	19
LMR	<10%	38	17	21	0.135
	≧10%	17	4	13
PLN	0,1,2	47	21	26	0.016	1.143	1.015–1.287	0.028
	≧3	8	0	8
ly	0	16	13	3	<0.001	1.795	1.112–2.896	0.017
	1,2,3	39	8	31
v	0	30	15	15	0.048	1.048	0.610–1.802	0.865
	1,2,3	25	6	19
ne	0	11	8	3	0.008	1.302	0.893–1.899	0.17
	1,2,3	44	13	31
HM	0	45	18	27	0.556
	1,2	10	3	7
EM	0	44	19	25	0.127
	1,2	11	2	9
PV	0	52	21	31	0.162
	1	3	0	3
A	0	53	21	32	0.258
	1	2	0	2
Stage	≦1	12	8	4	0.022	1.027	0.535–1.970	0.936
	2≦	43	13	30
R	0	36	16	20	0.188
	1,2	19	5	14

Abbreviations: BMI, body mass index; DLN, number of retrieved lymph nodes; LMR, lymph node metastasis ratio; PLN, number of positive lymph nodes; ly, lymphatic invasion; v, venous invasion; ne, perineural invasion; HM, proximal bile duct margin; EM, dissected margin; PV, portal system invasion; A, arterial system invasion; R, residual tumor.