Table 2.
Univariate and multivatiate analyses of relationship between various clinicopathological factors and overall survival (OS)
| Variable | Factors | Number | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|---|---|
| Alive | Dead | P-value | Hazard ratio | 95%CI | P-value | |||
| Sex | Male | 41 | 16 | 25 | 0.8 | |||
| Female | 14 | 6 | 8 | |||||
| Age | <70 | 28 | 13 | 15 | 0.322 | |||
| ≧70 | 27 | 9 | 18 | |||||
| BMI (kg/m2) | ＜25 | 47 | 20 | 27 | 0.349 | |||
| ≧25 | 8 | 2 | 6 | |||||
| Biliary tract | (+) | 48 | 17 | 31 | 0.069 | |||
| Decompression | (-) | 7 | 5 | 2 | ||||
| Macroscopic | flat infiltrating | 31 | 9 | 22 | 0.059 | |||
| Type | others | 24 | 13 | 11 | ||||
| Histological | tub1,pap | 24 | 11 | 13 | 0.437 | |||
| Type | others | 31 | 11 | 20 | ||||
| Tumor size | <20 | 13 | 7 | 6 | 0.244 | |||
| ≧20 | 42 | 15 | 27 | |||||
| T | 1,2 | 15 | 10 | 5 | 0.013 | 1.189 | 0.488–2.899 | 0.703 |
| 3 | 40 | 12 | 28 | |||||
| N | 0 | 31 | 14 | 17 | 0.375 | |||
| 1 | 24 | 8 | 16 | |||||
| M | 0 | 53 | 22 | 31 | 0.239 | |||
| 1 | 2 | 0 | 2 | |||||
| DLN | <13 | 25 | 10 | 15 | 1 | |||
| ≧13 | 30 | 12 | 18 | |||||
| LMR | <10% | 38 | 18 | 20 | 0.095 | |||
| ≧10% | 17 | 4 | 13 | |||||
| PLN | 0,1,2 | 47 | 22 | 25 | 0.012 | 1.151 | 1.017–1.303 | 0.026 |
| ≧3 | 8 | 0 | 8 | |||||
| ly | 0 | 16 | 13 | 3 | <0.001 | 1.644 | 1.029–2.628 | 0.038 |
| 1,2,3 | 39 | 9 | 30 | |||||
| v | 0 | 30 | 16 | 14 | 0.027 | 1.433 | 0.841–2.442 | 0.186 |
| 1,2,3 | 25 | 6 | 19 | |||||
| ne | 0 | 11 | 9 | 2 | 0.002 | 1.233 | 0.844–1.801 | 0.279 |
| 1,2,3 | 44 | 13 | 31 | |||||
| HM | 0 | 45 | 19 | 26 | 0.475 | |||
| 1,2 | 10 | 3 | 7 | |||||
| EM | 0 | 44 | 20 | 24 | 0.099 | |||
| 1,2 | 11 | 2 | 9 | |||||
| PV | 0 | 52 | 22 | 30 | 0.146 | |||
| 1 | 3 | 0 | 3 | |||||
| A | 0 | 53 | 22 | 31 | 0.239 | |||
| 1 | 2 | 0 | 2 | |||||
| Stage | ≦1 | 12 | 8 | 4 | 0.033 | 1.235 | 0.633–2.412 | 0.536 |
| 2≦ | 43 | 14 | 29 | |||||
| R | 0 | 36 | 17 | 19 | 0.132 | |||
| 1,2 | 19 | 5 | 14 | |||||
Abbreviations: BMI, body mass index; DLN, number of retrieved lymph nodes; LMR, lymph node metastasis ratio; PLN, number of positive lymph nodes; ly, lymphatic invasion; v,venous invasion; ne, perineural invasion; HM, proximal bile duct margin; EM, dissected margin; PV, portal system invasion; A, arterial system invasion; R, residual tumor.