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Inhibitory effect of single-dose lemborexant on the plasma ACTH increase induced by centrally applied [Ala11, D-Leu15]-orexin B in rats. Rats received single-dose oral doses of vehicle or lemborexant (1, 3, 10, or 30 mg/kg) (all n = 5, except for 30 mg/kg n = 4) during the light phase. #p < 0.05 versus i.c.v. PBS control (t-test); *p < 0.05 versus vehicle/[Ala11, D-Leu15]-orexin B (one-way analysis of variance followed by Dunnett multiple comparison test).
