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Effect of single-dose lemborexant on total sleep time (A) and REM sleep ratio (B) in rats. Rats received single oral doses of vehicle, lemborexant (3, 10, 30, 100, or 300 mg/kg), or zolpidem (3, 10, 30, or 100 mg/kg) (all n = 6) at Zeitgeber time 2:00–3:00 (Zeitgeber time 0:00 = lights on; Zeitgeber time 12:00 = lights off). Data are mean ± standard error of the mean for the 2 h after dosing. *p < 0.05 versus vehicle (mixed effect model followed by Dunnett multiple comparison test).
