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. 2019 Mar 29;42(6):zsz076. doi: 10.1093/sleep/zsz076

Table 1.

Lemborexant pharmacokinetic parameters in mice after dosing for sleep promotion (10 mg/kg, p.o.) and after maximum dosing in the ethanol-induced anesthesia and motor coordination safety paradigms (300 mg/kg, p.o.)

Parameter Lemborexant
10 mg/kg, p.o. 300 mg/kg, p.o.
C max (ng/mL) 437 7,340
t max (h) 0.5 3
AUC(0–24 h) (ng h mL−1) 998 72,400

AUC(0–24 h), area under the concentration–time curve from 0 to 24 h; Cmax, maximum concentration; p.o., oral administration; tmax, time to peak concentration after dosing.