Table 2.

Quality assessment of the included articles.

QUADAS list item	Reference number of the included studies
	1	2	3	4	5	6	7	8	9	10
1. Did the spectrum of patients represent the patients who will receive the test in practice?	+	0	+	0	+	+	0	+	+	+
2. Were selection criteria clearly described?	+	+	+	+	+	+	+	+	+	+
3. Is the reference standard likely to correctly classify the target condition?	+	+	+	+	+	+	+	+	+	+
4. Is the period between the reference standard and index test short enough to be reasonably sure that the target condition did not change between the 2 tests?	+	0	+	+	+	+	+	+	0	+
5. Did the entire sample or a random selection of the sample receive verification using a reference standard of diagnosis?	+	+	+	+	+	+	+	+	+	+
6. Did patients receive the same reference standard regardless of index test result?	+	+	+	+	+	+	+	+	+	+
7. Was the reference standard independent of the index test (i.e., index test did not form part of the reference standard)?	0	0	0	0	0	0	0	0	0	0
8. Was execution of the index test described in sufficient detail to permit replication of the test?	+	+	+	+	+	+	+	+	+	+
9. Was execution of the reference standard described in sufficient detail to permit its replication?	+	+	+	0	+	+	+	+	+	+
10. Were index test results interpreted without knowledge of results of the reference standard?	0	0	+	+	0	+	+	+	+	+
11. Were reference standard results interpreted without knowledge of results of the index test?	0	+	+	0	0	+	+	+	+	+
12. Were the same clinical data available when test results were interpreted as would be available when the test is used in practice?	0	0	0	0	0	0	0	0	0	0
13. Were uninterruptable/intermediate test results reported?	0	0	+	+	+	0	+	0	+	+
14. Were withdrawals from the study explained?	+	+	+	+	+	+	+	+	+	+