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. 2019 Apr 24;44(1):157–171. doi: 10.3892/ijmm.2019.4173

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Copyright: © Fan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Mechanism of SIRTs in inflammation and metabolism. SIRTs coordinate with each other and serve functions in regulating inflammation and metabolism. When the SIRT level is abnormal, inflammation and metabolic disorders may be caused via a variety of pathways, and then the production of psoriasis may be induced. SIRT, Sirtuin; NF-κB, nuclear factor-κB; TNF-α/β, tumor necrosis factor α/β; FOX3, fork head transcription factor 3; Akt, protein kinase B; eIF2a, Eukaryotic translation initiation factor 2A; NO, nitric oxide; IL, interleukin; ROS, reactive oxygen species; Mit, mitochondrial; HIF-1α hypoxia-inducible factor 1α; HIF2α, hypoxia-inducible factor 2α; K141, Lys-141; K143, Lys-143.