Figure 5:

Heat maps of Sobol’ total order index for the input parameters across different output populations. The values in the heat map indicate the Sobol’ total order sensitivity index obtained from the metamodel for the 38 input parameters with respect to the cell populations. The values with darker color indicate a stronger influence on the cell population as compared to the ones with lighter shade that indicate non-influential parameters for the cell populations: (a) H. pylori, (b) monocyte-derived macrophages, and (c) resident macrophages in the lamina propria compartment and (d) tolerogenic DCs in the gastric lymph node compartment. The indexes are calculated over 6 time points ranging across the 3 stages of infection, including initiation (Day 1–14), peak (Days 15–42), and recovery stages (Days 43–201). The detailed explanation of abbreviations for the parameters are in Table S1.