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. Author manuscript; available in PMC: 2019 Jun 11.
Published in final edited form as: Exp Neurol. 2019 Jan 17;314:58–66. doi: 10.1016/j.expneurol.2019.01.003

Figure 3. Inflammatory injury increases sensitivity to the Ca2+ permeable-AMPAR blocker, IEM-1460.

Figure 3.

IEM-1460 (50 μM, 10 min exposure) decreased AMPA-evoked [Ca2+]i in dorsal horn of CFA 21d but not uninflamed mice. **p<0.01 vs control Ca2+ response to AMPA (Dunnett’s post-hoc test following 2-way ANOVA with repeated measures). Data represent mean ± SEM, N = 8 mice/group.