Table 5. The modified score-based decision approach in the chronic myeloid leukemia patients after the acute toxic imatinib-induced liver injury treated with imatinib less than three months (points).

* This decision approach can be used in patients with less than three month of imatinib treatment and after the firstly appeared acute imatinib hepatitis or I-II grade of imatinib hepatotoxicity recurrence, if imatinib hepatitis recurs in III-IV grade of hepatotoxicity the imatinib withdrawal should be considered; All decisions to restart should be made after the resolving acute hepatitis and after the transaminases normalization as in previously reported cases;

** Imatinib can be restarted in the reduced or the same dose;

*** «Yes» – when hepatoxicity stops less than in one month and does not recurs, «No» – when the hepatoxicity does not stop after one month or recurs.

Factors	Imatinib restart*	Imatinib withdrawal
The grade of hepatotoxicity reaction
I grade	1	0
II grade	1**	0
III grade	1/0***	1/0
IV grade	0	1
The presence of the offender concomitant drug probably caused drug interaction
Yes	1	0
No	0	1
The presence of the viral hepatitis reactivation identified by Polymerase Chain Reaction (PCR+)
Yes	1	0
No	0	1