Table 7. The example of the score based decision approach in a chronic myeloid leukemia patient after the acute toxic imatinib-induced liver injury (imatinib restart).

Factors	Imatinib restart*
The grade of hepatotoxicity reaction
I grade
II grade	1
III grade
IV grade / the presence of the liver transplantation or imatinib-induced liver cirrhosis caused by drug interaction or viral hepatitis reactivation
The presence of EMR to the imatinib therapy defined as three-month BCR-ABL1IS ≤10%:
Yes	1
No
The presence of EMR to the imatinib therapy defined as six-month BCR-ABL1IS <1% (if applicable****):
Yes	1
No
The presence of the offender concomitant drug probably caused drug interaction
Yes
No	0
The presence of the viral hepatitis reactivation identified by Polymerase Chain Reaction (PCR+)
Yes
No	0