Table 1.
Demographics of the study population by country and birth cohort.
| Denmark |
UK |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1969–1977 | 1978–1987 | 1988–1997 | 1998–2007 | 2008–2009 | Total | 1969–1977 | 1978–1987 | 1988–1997 | 1998–2007 | 2008–2010 | Total | |
| n | 97 | 110 | 144 | 113 | 7 | 471 | 790 | 1852 | 2546 | 2011 | 387 | 7586 |
| Sex = male (%) | 51 (52.6) | 57 (51.8) | 66 (45.8) | 52 (46) | 4 (57.1) | 230 (48.8) | 452 (57.2) | 1023 (55.2) | 1309 (51.4) | 1003 (49.9) | 190 (49.1) | 3977 (52.4) |
| Ethnicity = white (%) | NA | NA | NA | NA | NA | NA | 779 (98.6) | 1799 (97.1) | 2474 (97.2) | 1906 (94.8) | 362 (93.5) | 7320 (96.5) |
| #F508del alleles(%) | ||||||||||||
| 0 | 0 (0.0) | 2 (1.8) | 0 (0.0) | 1 (0.9) | 0 (0.0) | 3 (0.6) | 71 (9.0) | 146 (7.9) | 202 (7.9) | 175 (8.7) | 43 (11.1) | 637 (8.4) |
| 1 | 6 (6.2) | 10 (9.1) | 8 (5.6) | 5 (4.4) | 0 (0.0) | 29 (6.2) | 354 (44.8) | 664 (35.9) | 929 (36.5) | 706 (35.1) | 143 (37.0) | 2796 (36.9) |
| 2 | 91 (93.8) | 98 (89.1) | 136 (94.4) | 107 (94.7) | 7 (100.0) | 439 (93.2) | 365 (46.2) | 1042 (56.3) | 1415 (55.6) | 1130 (56.2) | 201 (51.9) | 4153 (54.7) |
| Diagnosis by NBS (%) | NA | NA | NA | NA | NA | NA | 12 (1.5) | 92 (5.0) | 257 (10.1) | 444 (22.1) | 286 (73.9) | 1091 (14.4) |
| Mean IMD z-score (sd) | NA | NA | NA | NA | NA | NA | −0.10 (0.93) | 0.02 (0.96) | 0.02 (1.00) | −0.02 (1.01) | −0.07 (1.01) | −0.01 (0.99) |
| Pancreatic insufficient (%) | 91 (93.8) | 101 (91.8) | 137 (95.1) | 108 (95.6) | 7 (100.0) | 444 (94.3) | 658 (83.3) | 1690 (91.3) | 2361 (92.7) | 1813 (90.2) | 323 (83.5) | 6845 (90.2) |
| CFRD during study period (%) | 37 (38.1) | 33 (30.0) | 27 (18.8) | 1 (0.9) | 0 (0.0) | 98 (20.8) | 404 (51.1) | 882 (47.6) | 931 (36.6) | 271 (13.5) | 6 (1.6) | 2494 (32.9) |
| Chronic PA during study period (%) | 71 (73.2) | 52 (47.3) | 37 (25.7) | 10 (8.8) | 0 (0.0) | 170 (36.1) | 632 (80.0) | 1558 (84.1) | 1792 (70.4) | 577 (28.7) | 27 (7.0) | 4586 (60.5) |
| Mean age at diagnosis (sd) | 4.15 (7.43) | 2.42 (5.47) | 1.95 (3.04) | 1.84 (2.93) | 0.21 (0.21) | 2.46 (4.89) | 9.08 (13.11) | 3.69 (7.12) | 2.08 (4.03) | 1.11 (2.19) | 0.19 (0.60) | 2.85 (6.53) |
NBS: Newborn bloodspot screening; IMD: Index of multiple deprivation where higher scores equate to higher deprivation; CFRD: CF related diabetes; PA: Pseudomonas Aeruginosa