Table 1. Main characteristics of profilaggrin, filaggrin, and its degradation products (amino acids).

Profilaggrin (Mm > 400 kDa)	Filaggrin (Mm ≈ 37 kDa)	Amino acids (NMF)
Main constituent of keratohyalin granules, calcium-binding polyprotein, enucleation during cornification, keratinocyte-calcium signalling	Contribution to SC structure and function, aggregation of intermediate filaments, inhibition of transepidermal water loss	Epidermal hydration, acidification, photo protection, immunomodulation, antistaphyloccoccal effect
SC - stratum corneum. NMF - natural moisturizing factor. Mm – molecular mass. According to reference (27).