Table 2. Analytical coefficient of variation, within subject biological coefficient of variation and total change limit of different biochemical analytes.
| Analyte | Coefficient of variation, CVa% | Coefficient of variation, CVb% | Total change limit (TCL) |
|---|---|---|---|
| HDL- cholesterol | 3.7 | 7.3 | ± 10.9 |
| Albumin | 2.3 | 3.2 | ± 6.6 |
| Cholesterol | 4.2 | 5.95 | ± 12.1 |
| Creatinine | 1.8 | 5.95 | ± 5.9 |
| Glucose | 1.8 | 4.5 | ± 5.6 |
| LDL- cholesterol | 3.5 | 7.8 | ± 10.4 |
| Total Protein | 1.0 | 2.75 | ± 3.0 |
| Triglyceride | 3.5 | 19.9 | ± 13.8 |
| CRP | 2.6 | 42.2 | ± 22.3 |
| Ferritin | 10.4 | 14.2 | ± 29.6 |
| Folate | 6.9 | 24.0 | ± 22.6 |
| Vitamin B12 | 8.8 | 15.0 | ± 25.5 |
| Vitamin D | 4.8 | 11.3 | ± 14.3 |
| HbA1c | 1.2 | 1.9 | ± 3.5 |
| Haemoglobin | 1.5 | 2.85 | ± 4.4 |
| Zinc | 6.9 | 9.4 | ± 19.7 |
| Vitamin A | 3.5 | 19.0 | ± 13.6 |
| sTfR | 3.0 | 3.0 | ± 8.4 |
| HDL - high density lipoprotein. LDL - low density lipoprotein. CRP - C reactive protein. HbA1c - glycylated haemoglobin. sTfR - soluble transferrin receptor. CVb - within-subject biological coefficient of variation, obtained from Ricos (8), except for Vitamin A and Zinc for which between-subject biological coefficient variation was used. CVa% - analytical coefficient of variation. TCL - total change limit and is an absolute value derived from CVa and CVb using the formula √(2.77 CVa)2 + (0.5 CVb)2. | |||